APREMILAST

APREMILAST: Apremilast is a prescription drug used to treat certain types of inflammatory conditions, including psoriasis and psoriatic arthritis. It is available as an oral tablet under the brand name Otezla.

The mechanism of action of apremilast involves inhibiting an enzyme called phosphodiesterase-4 (PDE-4). By inhibiting PDE-4, apremilast reduces the levels of certain pro-inflammatory cytokines, such as TNF-alpha and IL-17, in the body. This helps to modulate the immune response and reduce inflammation associated with psoriasis and psoriatic arthritis.

The initial dose of apremilast is usually 10 mg taken orally once daily for the first 3 days. After the initial 3-day period, the dose is increased to 20 mg taken orally twice daily. The tablets should be swallowed whole and can be taken with or without food.

As with any medication, apremilast can cause side effects. The most common side effects include diarrhea, nausea, headache, upper respiratory infection, and nasopharyngitis. Less common side effects may include depression, suicidal thoughts, weight loss, and allergic reactions. It is important to notify a healthcare professional if any side effects persist or worsen.

Apremilast may interact with certain medications, so it is essential to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting apremilast. It is also important to note that apremilast may increase the risk of infection, so individuals with an active infection or a history of recurrent infections should exercise caution while taking this medication.

Overall, apremilast is a medication used to treat psoriasis and psoriatic arthritis by reducing inflammation. It is taken orally, with a gradual increase in dosage, and can have side effects that should be monitored. It is important to discuss the use of this medication with a healthcare professional to determine if it is the right treatment option for you.