CARBIMAZOLE

CARBIMAZOLE: CARBIMAZOLE is an antithyroid drug used primarily in the treatment of hyperthyroidism, a condition characterized by an overactive thyroid gland. It belongs to a class of drugs called thioamides.

The mechanism of action of carbimazole involves inhibiting the production of thyroid hormones by interfering with the process of iodine incorporation into the amino acid tyrosine, which is necessary for the synthesis of thyroid hormones. It also has immunosuppressive effects, reducing the activity of the immune system in the thyroid gland.

The usual starting dose of carbimazole in adults is 20-60 mg per day, which can be split into 2-3 divided doses. The maintenance dose is usually around 5-20 mg per day. The dose may vary depending on the severity of the hyperthyroidism, the individual response, and the guidance of a healthcare professional.

Common side effects of carbimazole include gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. Allergic reactions such as rash, itching, and fever are also possible. In rare cases, serious side effects like agranulocytosis (a decrease in white blood cell count), liver dysfunction, and bone marrow suppression may occur. Regular blood tests are usually required to monitor for any potential adverse effects.

It’s crucial to note that carbimazole is contraindicated in patients with agranulocytosis or a previous history of hypersensitivity to the drug. It should be used with caution in patients with liver disorders and during pregnancy, as it can cross the placenta and affect fetal thyroid function.

It’s important to consult a healthcare professional before starting carbimazole, as they can assess the individual’s specific condition, prescribe the appropriate dose, and monitor for any potential side effects or drug interactions.