CHLORHEXIDINE GLUCONATE

CHLORHEXIDINE GLUCONATE: Chlorhexidine gluconate is an antiseptic and antimicrobial agent commonly used in healthcare settings to prevent and control infection. It is available in various forms, including solutions, gels, mouthwashes, and wipes.

Mechanism of Action:
Chlorhexidine gluconate works by disrupting the cell membrane of microorganisms, leading to leakage of intracellular components and ultimately causing their death. It has a broad spectrum of activity against both gram-positive and gram-negative bacteria, as well as some viruses and fungi.

Use:
Chlorhexidine gluconate is used for various purposes, such as preoperative and postoperative skin preparation, disinfection of surgical instruments, and prevention of infection in wounds and burns. It is also commonly used as a mouthwash or oral rinse for oral hygiene to reduce bacterial growth and plaque formation.

Dose:
The appropriate dose of chlorhexidine gluconate depends on the specific indication and formulation used. For skin preparation, it is typically applied topically to the affected area. As an oral rinse, it is usually used in a dilution of 0.12% to 0.2% for 30 seconds to 2 minutes, twice daily.

Side Effects:
While chlorhexidine gluconate is generally safe to use, it may cause some side effects. Common side effects include temporary discoloration of teeth, gums, and tongue (especially with long-term use), altered taste sensation, dry mouth, mouth irritation, and staining of dental restorations. Allergic reactions such as rash and swelling can also occur, although they are rare.

In rare cases, chlorhexidine gluconate may cause more severe side effects, such as anaphylactic reactions or severe allergic reactions. It is important to seek medical attention if any unusual or severe symptoms occur.

It is worth mentioning that chlorhexidine gluconate should not be ingested or swallowed, as it is not intended for internal use and can be harmful if swallowed.