FOLIC ACID + BIOTIN + BENFOTIAMINE + ALPHA LIPOIC ACID + INOSITOL + CYANOCOBALAMIN + PYRIDOXAL-5-PHOSPATE
Folic Acid: Drug: Folic Acid
Use: Folic acid is a synthetic form of vitamin B9, which is essential for the synthesis and repair of DNA and for the production of red blood cells. It is used to treat or prevent folate deficiency, which can lead to various health problems such as anemia and birth defects in pregnant women.
Mechanism of Action: Folic acid is converted into its active form, methyltetrahydrofolate, in the body. This active form is involved in the transfer of methyl groups, which are necessary for the synthesis of DNA and other important molecules. By providing an adequate supply of folate, folic acid helps in maintaining normal cellular functions and promoting red blood cell production.
Dose: The recommended daily dose of folic acid varies depending on the age, sex, and specific indication. For adults, the typical dose range is 400 to 800 micrograms per day. Pregnant women are often advised to take higher doses, usually around 600 to 800 micrograms per day.
Side Effects: Folic acid is generally considered safe and well-tolerated when taken at recommended doses. However, some individuals may experience mild side effects such as nausea, loss of appetite, bloating, or a bitter taste in the mouth. In rare cases, allergic reactions may occur, characterized by symptoms like rash, itching, or difficulty breathing. High doses of folic acid can mask symptoms of vitamin B12 deficiency, potentially leading to nerve damage if left untreated. It is always recommended to consult a healthcare professional before starting folic acid or any other supplementation.
Biotin: Biotin is a water-soluble vitamin that belongs to the B-complex group. It is also known as vitamin B7 or vitamin H. Biotin is essential for various metabolic processes in the body, including the breakdown of carbohydrates, fats, and proteins.
Biotin is primarily used as a dietary supplement to prevent or treat biotin deficiency. It is often prescribed in cases of genetic disorders that affect biotin metabolism, such as biotinidase deficiency or multiple carboxylase deficiency. Biotin deficiency can lead to symptoms like hair loss, skin rashes, mild depression, fatigue, and more.
The mechanism of action of biotin involves its role as a coenzyme in various metabolic reactions. Biotin acts as a cofactor for enzymes involved in the synthesis and breakdown of fatty acids, amino acids, and glucose. It helps to activate these enzymes and aids in the metabolism of these essential molecules.
The recommended daily dose of biotin varies depending on the purpose of its use. For biotin deficiency, the usual adult dose is around 10-30 micrograms per day. For certain medical conditions like biotinidase deficiency, the dose may be higher, up to several milligrams per day. It is important to follow the specific dosing instructions provided by healthcare professionals.
Biotin is generally considered safe when taken within the recommended daily dose. It is a water-soluble vitamin, which means that excess amounts are excreted in the urine. As a result, biotin overdose is rare. However, some individuals may experience mild side effects such as nausea, diarrhea, and skin rashes.
It’s essential to consult a healthcare provider before starting any new supplement or medication, including biotin, to determine the appropriate dose and ensure it is safe and suitable for your specific conditions or needs.
Benfotiamine: Benfotiamine is a synthetic derivative of thiamine, which is also known as vitamin B1. It is commonly used as a dietary supplement to support overall health and treat specific medical conditions.
Benfotiamine is primarily used for its role in managing and preventing complications related to diabetes, particularly diabetic neuropathy. It has been shown to help improve nerve function, reduce pain and inflammation, and protect against oxidative stress associated with chronic hyperglycemia.
The mechanism of action of benfotiamine is believed to be related to its ability to increase the levels of thiamine phosphate esters, particularly thiamine pyrophosphate (TPP), within the cells. These esters are essential for various metabolic processes, including glucose metabolism and cellular energy production. By increasing TPP levels, benfotiamine helps enhance these metabolic pathways and alleviate the negative effects of high blood sugar levels.
The typical dose of benfotiamine can vary depending on the condition being treated. For diabetic neuropathy, a common dosage is 300 mg taken orally once or twice daily. However, it is important to follow the recommended dosage provided by a healthcare professional or as indicated on the product label.
Benfotiamine is generally well-tolerated, and side effects are rare. Some individuals may experience mild gastrointestinal symptoms, such as nausea or stomach upset, which usually resolve on their own. Allergic reactions are extremely rare but should be reported to a healthcare provider immediately if they occur.
It is important to note that while benfotiamine can be beneficial for managing diabetic complications, it is not a substitute for proper diabetes management, including blood sugar control and lifestyle modifications. It is always recommended to consult with a healthcare professional before starting any new supplement or medication.
Alpha Lipoic Acid: Alpha Lipoic Acid (ALA) is a powerful antioxidant that occurs naturally in the body and is also available as a dietary supplement. It is used to treat a variety of health conditions and has gained popularity as a potential treatment for diabetes, diabetic neuropathy, and weight loss.
ALA functions as a coenzyme in various metabolic reactions and plays an essential role in energy production within cells. It acts as an antioxidant, protecting the body’s cells from damage caused by free radicals and reducing oxidative stress. Additionally, ALA has anti-inflammatory properties and can enhance the function of other antioxidants, such as vitamins C and E and glutathione.
In the treatment of diabetes and diabetic neuropathy, ALA is believed to improve insulin sensitivity and help regulate blood sugar levels. It also has a neuroprotective effect, preventing or reducing nerve damage associated with diabetes.
The typical dose of ALA varies depending on the condition being treated. For general antioxidant support, doses of 200-600 mg per day are commonly recommended. Higher doses, up to 1,800 mg per day, are often used for specific medical conditions, such as neuropathy.
Although generally considered safe, ALA may cause some side effects. Common side effects include stomach upset, nausea, and skin rash. Rarely, ALA may lower blood sugar levels, leading to hypoglycemia, especially in individuals with diabetes. It may also interact with certain medications, so it’s important to consult with a healthcare professional before starting ALA supplementation.
In summary, Alpha Lipoic Acid is an antioxidant and coenzyme that is used to treat various health conditions, including diabetes and diabetic neuropathy. It works by reducing oxidative stress, improving insulin sensitivity, and protecting nerves. The dose of ALA varies depending on the condition, and side effects are generally mild but can include stomach upset and skin rash. As with any medication or supplement, it is recommended to consult a healthcare professional before using ALA.
Inositol: Drug: Inositol
Use:
Inositol, often referred to as vitamin B8, is a naturally occurring substance that is used as a dietary supplement. It plays a crucial role in various physiological processes in the body, including cell signaling, nerve function, and neurotransmitter regulation. Inositol has been studied for its potential therapeutic benefits in several conditions, including anxiety, depression, bipolar disorder, and polycystic ovary syndrome (PCOS).
Mechanism of Action:
The exact mechanism of action of inositol is not fully understood. It is believed to work by influencing the levels of certain neurotransmitters in the brain, such as serotonin and dopamine. Inositol also acts as a secondary messenger in the insulin signaling pathway, potentially helping to improve insulin sensitivity in individuals with PCOS.
Dose:
The appropriate dose of inositol can vary depending on the condition being treated. However, typical doses for general use range from 500 to 2000 mg per day, divided into two or three doses. It is important to follow the dosage instructions provided by the healthcare professional or supplement manufacturer to ensure safe and effective use.
Side Effects:
Inositol is generally considered safe and well-tolerated. However, some individuals may experience mild gastrointestinal side effects such as nausea, bloating, and diarrhea. These side effects are usually temporary and subside with continued use. In extremely high doses, inositol may cause drowsiness, dizziness, and headache. It is always advisable to consult with a healthcare professional before starting any new supplement to evaluate any potential risks or interactions with other medications.
Cyanocobalamin: Cyanocobalamin is a synthetic form of vitamin B12, which is essential for the production of red blood cells and the normal functioning of the nervous system. It is most commonly used to treat vitamin B12 deficiency, which can occur in individuals who have a poor diet, certain gastrointestinal disorders, or who are unable to absorb the vitamin from food.
The mechanism of action of cyanocobalamin involves its conversion into active forms of vitamin B12 in the body, such as methylcobalamin and adenosylcobalamin. These active forms are required for various enzymatic reactions in the body, particularly in the metabolism of amino acids and fatty acids.
The dose of cyanocobalamin varies depending on the individual’s condition and the severity of the deficiency. It can be administered orally, through intramuscular injections, or intranasally. The typical dose for vitamin B12 deficiency is 1000 mcg injected intramuscularly once daily for 6-7 days, followed by a monthly injection of the same dose as maintenance therapy. Oral cyanocobalamin can be taken in doses ranging from 250-2000 mcg daily.
While cyanocobalamin is generally well-tolerated, it may cause some side effects. These can include mild diarrhea, nausea, rash, headache, or itching at the injection site. In rare cases, allergic reactions can occur, presenting as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. If any serious side effects occur, it is important to seek medical attention immediately.
Pyridoxal-5-Phospate: Pyridoxal-5-Phosphate is the active form of vitamin B6, also known as pyridoxine. It is a water-soluble vitamin that plays an important role in many biological functions in the body.
Its primary use is as a dietary supplement to address vitamin B6 deficiency. It may also be prescribed by healthcare professionals for other medical conditions, such as certain types of anemia or nerve-related disorders.
Pyridoxal-5-Phosphate functions as a coenzyme in more than 100 enzymatic reactions in the body. It is essential for the metabolism of amino acids, carbohydrates, and lipids. By participating in these reactions, it helps in the production of neurotransmitters like serotonin, dopamine, and GABA. Additionally, it plays a role in maintaining normal nerve function, promoting red blood cell production, and supporting a healthy immune system.
The recommended dose of Pyridoxal-5-Phosphate varies depending on the individual’s age, sex, and specific medical condition. It is typically available as oral tablets or capsules, and it is important to follow the dosage instructions provided by the healthcare professional or as indicated on the product label.
While Pyridoxal-5-Phosphate is generally considered safe when taken at appropriate doses, some individuals may experience side effects. Common side effects may include nausea, vomiting, headache, and sleep disturbances. In rare cases, allergic reactions may occur, characterized by rash, itching, swelling, or difficulty breathing. If any of these side effects occur, it is important to seek medical attention promptly.
It is worth noting that excessive intake of vitamin B6, including Pyridoxal-5-Phosphate, can lead to side effects such as nerve damage or loss of sensation in the hands and feet. Therefore, it is vital to adhere to the recommended dosage and consult with a healthcare professional before starting any new supplement regimen.
