HYDROXYPROGESTERONE

HYDROXYPROGESTERONE: Hydroxyprogesterone is a synthetic medication that is used to prevent preterm labor and reduce the risk of premature birth in pregnant women who have a history of preterm delivery. It is available under the brand name Makena.

The exact mechanism of action of hydroxyprogesterone in preventing preterm labor is not fully understood. However, it is believed to work by providing progesterone, a naturally occurring hormone in the body, which helps to maintain pregnancy and prevent contractions of the uterus.

Hydroxyprogesterone is typically administered as an injection into the muscle (intramuscular injection). The recommended dose is 250 mg once weekly starting from the 16th to the 20th week of pregnancy until the 37th week (or until delivery if the pregnancy continues beyond 37 weeks). It is important to follow the dosing schedule as prescribed by a healthcare professional.

As with any medication, hydroxyprogesterone may cause certain side effects. The most common side effects include pain, swelling, and itching at the injection site. Some women may experience allergic reactions, such as hives, itching, difficulty breathing, or swelling of the face, lips, tongue, or throat. Other potential side effects may include headache, nausea, vomiting, breast tenderness, and spotting or bleeding between menstrual periods.

It is important to discuss any concerns or potential side effects with a healthcare professional before starting hydroxyprogesterone or any other medication. They can provide more personalized information based on individual circumstances and guide on the appropriate use of the drug.