ISOSORBIDE-5-MONONITRATE

ISOSORBIDE-5-MONONITRATE: Isosorbide-5-mononitrate is a drug used for the treatment and prevention of angina pectoris, a condition characterized by chest pain or discomfort caused by reduced blood flow to the heart muscle. It belongs to the class of drugs known as organic nitrates.

The main mechanism of action of isosorbide-5-mononitrate is its conversion to nitric oxide (NO) in the body. Nitric oxide is a vasodilator, meaning it relaxes and widens the blood vessels, increasing blood flow and oxygen supply to the heart. By dilating the coronary arteries, isosorbide-5-mononitrate helps to relieve the constriction and spasm of these vessels, reducing the workload of the heart and relieving angina symptoms.

The usual starting dose of isosorbide-5-mononitrate is 20 mg to 30 mg once daily, with the maximum recommended dose being 120 mg per day. The dose may be adjusted based on individual patient response and tolerability.

Some common side effects of isosorbide-5-mononitrate include headache, dizziness, lightheadedness, flushing, and nausea. These side effects are usually mild and transient. However, if they persist or worsen, it is important to consult a healthcare professional. Rare but serious side effects can include hypotension (low blood pressure), increased heart rate, and fainting. It is important to seek immediate medical attention if any of these severe side effects occur.

Isosorbide-5-mononitrate should not be abruptly discontinued, as it may lead to a rebound effect and worsening of angina symptoms. It is important to follow the prescribed dosing schedule and any instructions provided by healthcare professionals.

Overall, isosorbide-5-mononitrate is an effective medication for the treatment and prevention of angina pectoris. It works by dilating the blood vessels and increasing blood flow to the heart, relieving chest pain. Like any medication, it is important to use it under the guidance of a healthcare professional and be aware of potential side effects.