KETOROLAC TROMETHAINE
KETOROLAC TROMETHAINE: Ketorolac tromethamine, also known by its brand names Toradol and Acular, is a non-steroidal anti-inflammatory drug (NSAID) used for its analgesic (pain-relieving) and anti-inflammatory properties. It is available in both oral and injectable forms.
Ketorolac is commonly used for the short-term management of moderate-to-severe pain, such as postoperative pain, musculoskeletal pain, and pain due to kidney stones. It is not recommended for chronic pain management or for long-term use.
The mechanism of action of ketorolac involves inhibiting the synthesis of prostaglandins, which are substances released in the body that cause pain and inflammation. By decreasing prostaglandin production, ketorolac helps to alleviate pain and reduce inflammation.
The dosage of ketorolac depends on the route of administration and the severity of the pain. The typical oral dose for adults is 10 mg every 4-6 hours, not exceeding 40 mg in a day. Injectable ketorolac is usually administered as a single dose of 30 mg, with a maximum of 60 mg in a day. It is important to follow the prescribed dosage and duration of treatment as directed by a healthcare professional.
Like all medications, ketorolac can cause side effects. Common side effects include nausea, indigestion, headache, dizziness, drowsiness, and sweating. Less common but potentially serious side effects include gastrointestinal bleeding, kidney damage, allergic reactions, and increased risk of cardiovascular events such as heart attack or stroke. These serious side effects are generally more common with long-term use or at higher doses.
Ketorolac should be used with caution in individuals with a history of gastric ulcers, kidney dysfunction, heart disease, or those who are at risk for bleeding disorders. It is contraindicated in patients with advanced kidney disease, active bleeding or a history of bleeding disorders, and those with asthma who are sensitive to aspirin or other NSAIDs.
It is essential to seek medical advice before starting ketorolac or any NSAID, especially in elderly patients or those with pre-existing medical conditions. The medication should not be used for more than five days due to an increased risk of adverse effects. It is best to follow the recommended dose and duration of use, as instructed by a healthcare professional.
