LEUCOVORIN

LEUCOVORIN: Leucovorin, also known as folinic acid or citrovorum factor, is a medication used to prevent and treat certain types of anemia caused by a deficiency of folic acid. It is also used in combination with other chemotherapy drugs to enhance their effectiveness and reduce certain side effects.

The mechanism of action of leucovorin involves its conversion to the active form of folic acid, which then serves as a coenzyme in various metabolic pathways. Folic acid is essential for the synthesis of DNA, RNA, and proteins, as well as for the production of red blood cells. By providing additional folate, leucovorin helps to support these processes and overcome folic acid deficiencies.

The dose of leucovorin varies depending on the indication and the specific treatment regimen. It is available in oral form as tablets or intravenous (IV) form as a solution. The recommended dose will be determined by the prescribing healthcare professional.

Common side effects of leucovorin may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal discomfort. These side effects are generally mild and temporary. Allergic reactions are rare but can occur, and individuals should seek medical attention if they experience symptoms such as rash, itching, swelling, or difficulty breathing.

Leucovorin should not be used in patients with a known allergy to folinic acid or folic acid. It should also be used with caution in patients with kidney and liver problems. As with any medication, it is important to discuss all potential risks and benefits with your healthcare provider before starting leucovorin.