METHYLCOBALAMIN + CALCITRIOL + LYCOPENE + OMEGA-3 FATTY ACIDS + CALCIUM CITRATE MALATE + L-METHYLFOLATE + VITAMIN K2-7 (MENAQUINONE-7) + PYRIDOXAL-5-PHOSPATE
Methylcobalamin: Methylcobalamin is a form of vitamin B12 that is commonly used as a supplement or medication. It plays a crucial role in the production of red blood cells and the functioning of the nervous system.
Methylcobalamin is often prescribed to individuals who have a deficiency in vitamin B12, which can be caused by conditions such as pernicious anemia, gastrointestinal disorders, or a vegan/vegetarian diet. It is also used for the treatment of diabetic neuropathy, a condition that causes nerve damage and pain in individuals with diabetes.
The mechanism of action of methylcobalamin involves its conversion to coenzyme B12 in the body, which is essential for various biochemical processes. Coenzyme B12 is involved in the synthesis of DNA, the production of myelin sheath (protective covering) around nerves, and the conversion of homocysteine to methionine. By supporting these processes, methylcobalamin helps in the maintenance and repair of nerve cells, blood cells, and DNA.
The dosage of methylcobalamin may vary depending on the specific condition it is being used to treat. As a general guideline, the recommended oral dose for vitamin B12 deficiency is 1,000 to 2,000 micrograms per day. However, the dosage should be determined by a healthcare professional based on individual needs and medical history.
Methylcobalamin is generally safe and well-tolerated. However, like any medication, it can have potential side effects. Common side effects may include headache, nausea, diarrhea, and injection site reactions (if given as an intramuscular injection). Allergic reactions are rare but possible. It is advisable to consult a healthcare professional if any side effects appear or persist.
It is important to note that while methylcobalamin is a readily available supplement, it is recommended to seek medical advice before starting any new medication or supplement. A healthcare professional can assess your specific needs and provide appropriate guidance regarding the use of methylcobalamin.
Calcitriol: Calcitriol is a medication that belongs to the class of drugs known as vitamin D analogs. It is a synthetic form of the active metabolite of vitamin D, known as calcitriol or 1,25-dihydroxyvitamin D3.
Calcitriol is primarily prescribed for the treatment of conditions where the body has difficulty absorbing an adequate amount of calcium from the diet, such as hypocalcemia, hypoparathyroidism, and renal osteodystrophy. It is also used in the management of certain bone disorders, including osteoporosis and osteomalacia.
The main mechanism of action of calcitriol involves acting as a prohormone for the active form of vitamin D. It binds to the vitamin D receptor in target tissues, which results in the stimulation of calcium and phosphate absorption in the intestines. Calcitriol also promotes bone mineralization by increasing the synthesis of proteins involved in bone formation.
The specific dosage of calcitriol depends on the individual patient and the condition being treated. It is usually taken orally, with the dose ranging from 0.25 to 1.0 mcg per day. The prescribed dosage should be determined by a healthcare professional.
While calcitriol is generally well-tolerated, it can still cause some side effects. Common side effects may include weakness, headache, dizziness, nausea, vomiting, dry mouth, constipation, and increased thirst. In rare cases, high doses of calcitriol may lead to excessive calcium levels in the blood, which can cause symptoms like confusion, increased urination, irregular heartbeat, and bone pain. It is crucial to monitor calcium levels regularly while taking this medication.
It is essential to inform the prescribing healthcare professional about any allergies or pre-existing medical conditions before starting calcitriol. Additionally, it is important to disclose all other medications, including over-the-counter drugs and supplements, to avoid potential interactions.
Overall, calcitriol is an effective medication for managing conditions related to calcium absorption and bone health. Strict adherence to the prescribed dosage and regular monitoring can help minimize the risk of side effects and optimize therapeutic benefits.
Lycopene: Lycopene is a naturally occurring substance that is responsible for the red color in tomatoes, watermelon, and other fruits and vegetables. It is classified as a carotenoid, a type of pigment that acts as an antioxidant in the body.
The primary use of lycopene is as a dietary supplement. It is often taken for its potential health benefits, including its role in promoting prostate health and reducing the risk of certain types of cancer, particularly prostate, lung, and stomach cancer. Lycopene is also believed to have antioxidant and anti-inflammatory effects, which may help protect against cellular damage caused by free radicals.
The exact mechanism of action of lycopene is not fully understood, but it is thought to work by neutralizing free radicals and reducing oxidative stress in the body. It is also believed to have potential anti-cancer effects by influencing various cellular processes and signaling pathways.
Lycopene is available in the form of capsules or tablets and is typically taken as a dietary supplement. The recommended dose of lycopene varies depending on the specific condition being targeted. For general health and antioxidant support, typical doses range from 4 to 10 milligrams per day. Higher doses, up to 30 milligrams per day, may be used for specific health conditions under the supervision of a healthcare professional.
Lycopene is generally considered safe for most people when taken in recommended doses. However, it may cause some side effects, although they are rare. These potential side effects include digestive issues such as stomach cramps, nausea, and diarrhea. In some cases, lycopene may cause a harmless but temporary discoloration of the skin, giving it an orange or yellowish tint. This effect is more likely to occur with high doses of lycopene.
It is important to note that lycopene supplements should not be used as a substitute for a healthy diet rich in fruits and vegetables. It is always advisable to consult with a healthcare professional before starting any new dietary supplement to ensure its safety and appropriateness for individual needs.
Omega-3 Fatty Acids: Omega-3 fatty acids are a type of polyunsaturated fatty acids that are commonly found in fish oils and certain plant sources. They are essential nutrients that play a vital role in the body’s overall health and well-being.
Omega-3 fatty acids are often used as a dietary supplement to promote cardiovascular health, reduce inflammation, and support brain function. They have been shown to have a positive effect on reducing triglyceride levels, lowering blood pressure, and preventing the formation of blood clots. Additionally, omega-3 fatty acids may also provide benefits for mental health conditions such as depression and anxiety.
The mechanism of action of omega-3 fatty acids is not fully understood, but it is believed that they exert their effects through several pathways. They can help reduce inflammation by influencing the production of inflammatory cytokines and prostaglandins. Omega-3 fatty acids also play a role in maintaining cell membrane fluidity, which can affect cell signaling and function.
The recommended dose of omega-3 fatty acids varies depending on the specific health condition being targeted. However, a typical daily dose ranges from 1 to 4 grams, which usually involves taking fish oil capsules. It is important to follow the instructions and dosage recommendations provided by the manufacturer or healthcare professional.
While generally considered safe, there are some potential side effects associated with omega-3 fatty acid supplementation. These may include gastrointestinal issues such as diarrhea, indigestion, and fishy aftertaste. In rare cases, high doses of omega-3 fatty acids may increase the risk of bleeding. Therefore, individuals taking blood thinning medications or who have bleeding disorders should exercise caution and consult with their healthcare provider before taking omega-3 fatty acid supplements.
Overall, omega-3 fatty acids are a widely used and well-tolerated dietary supplement that provides various health benefits. However, it is always advisable to consult with a healthcare professional before starting any new supplement regimen, especially if you have any underlying health conditions or are taking other medications.
Calcium Citrate Malate: Calcium Citrate Malate is a calcium supplement that is used to maintain healthy levels of calcium in the body. It is commonly prescribed to individuals who are at risk of developing calcium deficiencies, such as those with osteoporosis, menopausal women, and individuals with an inadequate calcium intake.
The mechanism of action of Calcium Citrate Malate involves providing the body with a source of bioavailable calcium. Calcium is an essential mineral that is necessary for numerous functions in the body, including bone health, muscle contraction, nerve transmission, and blood clotting. Calcium Citrate Malate is easily absorbed by the body due to its high solubility, making it an effective calcium supplement.
The recommended dose of Calcium Citrate Malate varies depending on the individual’s age, sex, and specific medical condition. It is commonly taken as a tablet or capsule and is typically recommended to be taken with meals for optimal absorption. It is important to follow the dosage instructions provided by the healthcare professional or the product label.
While Calcium Citrate Malate is generally well-tolerated, there are some potential side effects that may occur. These can include gastrointestinal symptoms such as constipation, bloating, gas, and stomach upset. In rare cases, excessive intake of calcium supplements may lead to hypercalcemia, which is characterized by symptoms such as nausea, vomiting, increased thirst, increased urination, and weakness. It is important to consult a healthcare professional if any concerning side effects occur.
It is also worth mentioning that Calcium Citrate Malate may interact with certain medications, such as antibiotics, thyroid medications, and certain diuretics. Therefore, it is essential to inform your healthcare provider about all the medications, including over-the-counter drugs and supplements, that you are currently taking before starting Calcium Citrate Malate.
Overall, Calcium Citrate Malate is an effective calcium supplement that can help maintain healthy calcium levels in the body. However, it is important to use it as directed by a healthcare professional and to be mindful of potential side effects and interactions with other medications.
L-Methylfolate: L-Methylfolate, also known as Levomefolic acid or 5-MTHF, is a synthetic form of folate, a naturally occurring B-vitamin. It is used as a prescription medication to treat certain medical conditions related to folate deficiency or impaired folate metabolism.
The primary mechanism of action of L-Methylfolate is its role as a methyl donor in various biochemical reactions. It acts as a necessary cofactor for the production of neurotransmitters such as serotonin, dopamine, and norepinephrine. By replenishing folate levels in the body, L-Methylfolate helps support proper functioning of the nervous system.
L-Methylfolate is commonly prescribed in cases where there is an inadequate response to antidepressant medications, particularly in patients with major depressive disorder (MDD) and treatment-resistant depression. It can enhance the effectiveness of antidepressant treatment and improve mood symptoms.
The recommended doses of L-Methylfolate may vary depending on the specific medical condition being treated. For the augmentation of antidepressant therapy, a typical starting dose is 7.5 mg per day, which can be gradually increased up to 15 mg per day if necessary. The medication is usually taken orally, with or without food.
As with any medication, L-Methylfolate may cause certain side effects. Common side effects may include mild digestive issues such as nausea, stomach upset, and bloating. In rare cases, allergic reactions may occur, characterized by symptoms like rash, itching, swelling, severe dizziness, or difficulty breathing. If any concerning side effects are experienced, it is advisable to seek medical attention promptly.
L-Methylfolate is generally well-tolerated, but it is important to consult with a healthcare professional before starting this medication, especially if there is a known allergy or sensitivity to folate supplements. Additionally, certain medical conditions and medications may interfere with the use of L-Methylfolate, so it is important to disclose all existing medical conditions and medications to the prescribing physician.
Vitamin K2-7 (menaquinone-7): Vitamin K2-7, also known as menaquinone-7, is a nutrient that belongs to the vitamin K family. It is a fat-soluble vitamin that plays a crucial role in blood clotting, bone health, and cardiovascular health.
The primary use of Vitamin K2-7 is to support bone health. It works by activating proteins that help regulate calcium metabolism and promote the accumulation of calcium in bones. This prevents calcium from depositing in the arteries and other soft tissues, reducing the risk of cardiovascular disease. Vitamin K2-7 also helps in the production of osteocalcin, a protein necessary for bone formation.
The recommended dose of Vitamin K2-7 varies depending on age, sex, and individual needs. However, a common dosage ranges from 45 to 180 micrograms per day. It is typically taken orally as a supplement. It is important to follow the recommended dosage and consult a healthcare professional for personalized advice.
Vitamin K2-7 is generally considered safe when taken in the recommended doses. However, some individuals may experience mild side effects such as nausea, stomach upset, and diarrhea. High doses of vitamin K2-7 may interfere with anticoagulant medications, so caution should be exercised when taking it in combination.
It’s important to note that vitamin K2-7 supplements should not be used as a substitute for a balanced diet. It is always best to obtain nutrients from a varied and healthy diet that includes foods rich in vitamin K2-7, such as fermented foods, cheese, eggs, and meat. Before beginning any new supplement regimen, it is advisable to consult a healthcare professional.
Pyridoxal-5-Phospate: Pyridoxal-5-phosphate, also known as PLP or P5P, is the active form of vitamin B6. It is an important coenzyme involved in several metabolic processes in the body.
PLP is primarily used as a therapeutic agent for vitamin B6 deficiency. It is also used in the treatment of certain neurological conditions such as neuropathy, seizures, and cognitive disorders. Additionally, it is sometimes used as a supplement for individuals with certain genetic disorders that impair the body’s ability to convert pyridoxine into its active form.
The mechanism of action of PLP involves its role as a coenzyme in many enzymatic reactions. It participates in over 100 enzymatic reactions, predominantly in amino acid metabolism and neurotransmitter synthesis. PLP is particularly important in the metabolism of proteins and in the synthesis of neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA).
The dose of PLP depends on the specific medical condition being treated. For vitamin B6 deficiency, the typical recommended daily dose is 25-50 mg. However, doses can vary based on individual needs and should be determined by a healthcare professional. Higher doses may be required for neurological conditions and should be prescribed by a doctor.
Like any medication, PLP can have potential side effects. Common side effects include nausea, vomiting, diarrhea, abdominal pain, and headache. In rare cases, allergic reactions such as rash or itching may occur. It is important to consult with a healthcare provider if any adverse effects are experienced.
It is worth noting that PLP should not be confused with pyridoxine, which is the inactive form of vitamin B6 commonly found in dietary supplements. PLP is the biologically active form that the body can readily utilize.
