METHYLERGOMETRINE
METHYLERGOMETRINE: Methylergometrine is a medication that belongs to the class of drugs known as ergot alkaloids. It is primarily used in the treatment of postpartum hemorrhage (excessive bleeding after childbirth) and for the prevention and management of uterine atony (lack of uterine contractions) following childbirth or abortion.
The main mechanism of action of methylergometrine is through its agonistic effects on alpha-adrenergic, dopamine, and serotonin receptors. It directly stimulates the smooth muscles of the uterus, leading to increased uterine contractions and a reduction in postpartum bleeding.
Methylergometrine is typically administered as an injection, either intramuscularly or intravenously. The recommended adult dose for postpartum hemorrhage is 0.2 mg (200 mcg) given intramuscularly. For the prevention and management of uterine atony, the usual dose is 0.2 mg (200 mcg) given by intravenous injection. The dosage may vary based on the specific situation and the healthcare provider’s discretion.
Like any medication, methylergometrine can cause side effects. The more common side effects include nausea, vomiting, headache, dizziness, abdominal pain, and high blood pressure. Other rare but serious side effects may include coronary artery vasospasm (which can lead to chest pain or heart attack), seizures, hallucinations, and allergic reactions. Methylergometrine should be used with caution in patients with a history of cardiovascular disease or hypertension.
It is important to note that methylergometrine should not be used during pregnancy as it may cause uterine contractions and potential harm to the fetus. It is also contraindicated in patients with certain medical conditions such as hypertension, preeclampsia, eclampsia, coronary artery disease, and peripheral vascular disease.
Overall, methylergometrine is a medication commonly used to reduce postpartum bleeding and manage uterine atony following childbirth or abortion. It works by stimulating uterine contractions and should be used under the guidance of a healthcare professional.
