NEOMYCIN SULPHATE
NEOMYCIN SULPHATE: Neomycin sulfate is an antibiotic used to treat bacterial infections. It belongs to the class of drugs known as aminoglycosides.
Mechanism of Action:
Neomycin works by inhibiting bacterial protein synthesis. It binds to the bacterial ribosome and interferes with the production of proteins essential for bacterial growth and survival. This ultimately leads to the death of the bacteria.
Use:
Neomycin is primarily used to prevent or treat infections caused by susceptible bacteria. It is commonly used in topical formulations to treat skin infections and in oral preparations to reduce gut bacterial populations before surgical procedures. It is also used in combination with other antibiotics for the treatment of certain types of infections.
Dose:
The dose of neomycin varies depending on the form of medication and the condition being treated. It can be administered orally, topically, or intravenously. The dose must be determined by a healthcare professional based on individual factors such as the patient’s age, weight, and specific infection.
Side Effects:
The use of neomycin can be associated with certain side effects, including:
1. Nephrotoxicity: Neomycin can cause kidney damage, especially when high doses are used or if the drug is given for prolonged periods.
2. Ototoxicity: Neomycin can cause damage to the inner ear, leading to hearing loss or balance problems. This is more common with long-term or high-dose therapy.
3. Hypersensitivity reactions: Some individuals may develop allergic reactions to neomycin, including rash, itching, swelling, or difficulty breathing. Serious allergic reactions are rare.
4. Gastrointestinal effects: Neomycin can disrupt the normal gut flora, leading to diarrhea and other gastrointestinal disturbances.
5. Interactions with other drugs: Neomycin can interact with other medications, including certain diuretics and neuromuscular blocking agents, which can potentiate their effects.
It is important to note that neomycin should not be used in individuals with known hypersensitivity to the drug or those with pre-existing kidney or hearing problems. It should also be used with caution in pregnant or breastfeeding women.
