NOT AVAILABLE + TOLVAPTAN
Not Available: I’m sorry, but as an AI language model, I cannot provide specific information about a drug named “Not Available.” It is likely that “Not Available” is not the actual name of a drug, but rather a placeholder for a drug that could not be identified or specified.
If you have any other specific drug names or medical questions, I would be happy to try and assist you.
Tolvaptan: Tolvaptan is a medication used to treat a condition called hyponatremia, which is characterized by low levels of sodium in the blood. It is also used to slow the progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD) in adults.
The mechanism of action of Tolvaptan is through its selective action on the vasopressin V2 receptors in the kidneys. Vasopressin, also known as antidiuretic hormone (ADH), normally acts on these receptors to increase water reabsorption in the kidneys, leading to a decrease in urine output. Tolvaptan acts as a vasopressin receptor antagonist, blocking the action of vasopressin, thus increasing urine flow and reducing water reabsorption. This helps to correct hyponatremia and slows the progression of ADPKD.
The recommended starting dose of Tolvaptan for hyponatremia is 15 mg once daily, which can be increased or decreased based on the patient’s response and tolerance. For ADPKD, the recommended starting dose is 45 mg once daily, with a possible increase to 60 mg or 90 mg depending on kidney function and tolerance. Tolvaptan should be taken with water, and it is important to follow the prescribed dose and frequency as directed by a healthcare professional.
Like any medication, Tolvaptan can cause side effects. Common side effects include thirst, dry mouth, increased urination, and increased blood sodium levels. Other potential side effects include dizziness, weakness, headache, diarrhea, and hyperglycemia. It is important to consult a healthcare provider if any side effects are experienced or if there are concerns about its use. Tolvaptan may not be suitable for individuals with certain medical conditions or those taking certain medications, so it is necessary to discuss the medication thoroughly with a healthcare professional before starting treatment.
