PARACETAMOL (ACETAMENOPHEN) + IBUPROFEN

Paracetamol (acetamenophen): Paracetamol, also known as acetaminophen, is a commonly used over-the-counter medication for the relief of mild to moderate pain and fever. It is available in various forms such as tablets, capsules, liquid suspension, and suppositories.

The exact mechanism of action of paracetamol is not fully understood. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol has minimal anti-inflammatory effects. It is believed to work by inhibiting cyclooxygenase (COX) enzymes in the central nervous system, which leads to a reduction in the production of certain prostaglandins, substances that contribute to pain and fever.

The recommended dose of paracetamol for adults is usually 500 to 1000 milligrams (mg) every 4 to 6 hours, with a maximum daily dose of 4 grams (4000 mg). For children, the dosage is weight-based and can be given as a suspension or chewable tablet.

Paracetamol is generally well-tolerated when taken at recommended doses. However, excessive use or overdose can cause severe liver damage, so it is important to follow the recommended dosage and avoid combining it with other medications containing paracetamol. Common side effects of paracetamol include rare skin reactions such as rash or itching. Serious side effects, such as liver damage, are rare but can occur if the recommended dose is exceeded or if it is used in combination with alcohol. It is important to seek immediate medical attention if signs of an overdose or liver damage, such as yellowing of the skin or eyes, dark urine, or abdominal pain, are observed.

It is essential to read and follow the instructions provided with the medication and consult a healthcare professional for proper use and dosing of paracetamol, especially in individuals with liver disease, alcoholism, or those taking other medications.

Ibuprofen: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) commonly used to treat various types of pain, inflammation, and fever. It is available over-the-counter and also in higher strengths with a prescription.

The primary mechanism of action of ibuprofen is the inhibition of cyclooxygenase (COX) enzymes. These enzymes produce prostaglandins, which are responsible for pain, inflammation, and fever. By inhibiting COX enzymes, ibuprofen reduces the production of prostaglandins, thereby reducing pain and inflammation.

The usual recommended dose of ibuprofen for adults is 200-400 mg orally every 4-6 hours, not exceeding 1,200 mg per day. However, the exact dosage and duration of treatment may vary depending on the individual’s condition and the doctor’s recommendation. It is important to follow the instructions on the label or as prescribed by the healthcare professional.

While ibuprofen is generally considered safe and well-tolerated, it can cause some side effects. Common side effects may include gastrointestinal disturbances such as stomach pain, heartburn, nausea, and diarrhea. In some cases, ibuprofen can also lead to stomach ulcers or bleeding, particularly if used for a long duration or at high doses. Other side effects may include headache, dizziness, drowsiness, allergic reactions, and increased blood pressure.

It is important to note that ibuprofen may interact with certain medications and medical conditions. It is recommended to consult a healthcare professional or pharmacist before using ibuprofen, especially if you have a history of gastrointestinal ulcers, kidney problems, high blood pressure, or if you are taking other medications such as blood thinners or steroids.

In summary, ibuprofen is an NSAID used to relieve pain, inflammation, and fever. It works by inhibiting COX enzymes and reducing the production of prostaglandins. The recommended dose varies depending on the condition but should not exceed 1,200 mg per day. Common side effects include gastrointestinal disturbances, headaches, and drowsiness. It is important to use ibuprofen responsibly and consult a healthcare professional if needed.