PROPOFOL

PROPOFOL: Propofol is a short-acting intravenous anesthetic drug commonly used for induction and maintenance of general anesthesia, sedation during medical procedures, and sedation of ventilated patients in intensive care units.

The mechanism of action of propofol is not fully understood, but it is thought to enhance the inhibitory actions of the neurotransmitter GABA in the central nervous system. This results in sedation, hypnosis, and amnesia. Propofol also has antiemetic properties, meaning it can prevent or reduce nausea and vomiting.

The dose of propofol can vary depending on the desired level of sedation or anesthesia and the patient’s individual characteristics. For induction of anesthesia, a typical dose range is 1.5-2.5 mg/kg. Maintenance doses are lower and usually range from 4-12 mg/kg/hour. These doses are administered intravenously.

Common side effects of propofol include pain or burning at the injection site, hypotension (low blood pressure), bradycardia (slow heart rate), respiratory depression, and coughing or hiccups. These side effects are generally mild and transient. Rare but serious side effects may include severe allergic reactions, propofol infusion syndrome (a rare and potentially life-threatening condition characterized by metabolic acidosis, cardiac dysfunction, and rhabdomyolysis), and infection at the injection site.

It is important to note that propofol should only be administered by trained medical professionals in a controlled clinical setting due to its potential for respiratory depression and cardiovascular effects.