Aceclofenac: Aceclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce inflammation in various conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It belongs to the class of drugs known as phenylacetic acids.

The exact mechanism of action of aceclofenac is not fully understood, but it is believed to work by inhibiting the production of prostaglandins, which are substances that cause pain, inflammation, and fever in the body. By reducing the levels of prostaglandins, aceclofenac helps alleviate pain and inflammation.

The recommended dose of aceclofenac may vary depending on the condition being treated. In general, the usual adult dose is 100-200 mg once daily, preferably taken after food. It is important to follow the dosage instructions provided by the healthcare professional or the package label.

As with any medication, aceclofenac may cause certain side effects. Common side effects include gastrointestinal disturbances such as stomach pain, indigestion, nausea, vomiting, and diarrhea. Less frequently, it may cause dizziness, headache, skin rash, and itching. In rare cases, aceclofenac can lead to severe adverse effects such as allergic reactions, liver damage, kidney problems, and cardiovascular events. It is advised to immediately seek medical attention if experiencing any serious side effects.

It is important to note that aceclofenac should be used with caution in individuals with a history of gastrointestinal disorders, heart problems, kidney or liver disease, or those who are pregnant or breastfeeding. It may also interact with other medications, so it is essential to inform the healthcare provider about all current medications before starting aceclofenac.

In summary, Aceclofenac is an NSAID used to treat pain and inflammation in conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It inhibits the production of prostaglandins in the body, which helps reduce pain and inflammation. The recommended dose varies depending on the condition, and common side effects include gastrointestinal disturbances. It is important to use aceclofenac cautiously and under the guidance of a healthcare professional.

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Paracetamol Brands/combinations: Paracetamol, also known as acetaminophen, is a commonly used over-the-counter medication. It is available under various brand names and is often combined with other drugs to provide relief from pain and reduce fever. Some common brand names for paracetamol combinations include Tylenol, Panadol, and Calpol.

Paracetamol is primarily used for the management of mild to moderate pain and fever. It can be used for a variety of conditions, including headaches, toothaches, muscle aches, colds, flu, and fever associated with viral infections.

Mechanism of Action:
The exact mechanism by which paracetamol works is not fully understood, but it is believed to involve the inhibition of prostaglandin synthesis in the central nervous system, resulting in a reduction in pain and fever. Paracetamol does not possess significant anti-inflammatory properties, unlike nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen.

The recommended dose of paracetamol varies depending on the age and weight of the patient, as well as the specific formulation. It is important to follow the instructions provided on the packaging or consult a healthcare professional for the appropriate dose.

Side Effects:
Paracetamol is generally well-tolerated when used within the recommended dose range. However, high doses or long-term use can cause liver damage. It is important to avoid exceeding the maximum recommended daily dose. Other potential side effects include allergic reactions (such as skin rash and hives), blood disorders, and kidney damage. Some individuals may also experience gastrointestinal upset, but this is less common compared to NSAIDs.

It is important to note that while paracetamol is generally safe, it can interact with other medications and medical conditions. It is always advisable to consult with a healthcare professional or pharmacist before using paracetamol, especially if you have existing liver disease, if you are taking other medications, or if you are pregnant or breastfeeding.

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