Endothelin receptor antagonists are a type of medication that block the action of endothelin receptors, which are involved in regulating blood vessel constriction. These drugs are used to treat conditions such as pulmonary arterial hypertension, a condition characterized by high blood pressure in the arteries of the lungs. By inhibiting endothelin receptors, these medications help to relax and widen the blood vessels, improving blood flow and reducing the workload on the heart.

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