CALCIUM + CHROMIUM PICOLINATE + MELATONIN + VITAMIN D3 (CHOLECALCIFEROL) + L-METHYLFOLATE + MYO-INOSITOL + D-CHIRO INOSITOL
Calcium: Drug: Calcium
Use: Calcium is used as a mineral and electrolyte supplement. It is primarily prescribed to treat or prevent calcium deficiency, as well as a supplement for conditions like osteoporosis, hypoparathyroidism, and rickets.
Mechanism of Action: Calcium is an essential mineral for various bodily functions, including bone formation, muscle contraction, nerve transmission, and blood clotting. It works by increasing the levels of calcium in the body, helping to maintain normal calcium levels when they are low.
Dose: The recommended dosage of calcium varies depending on the specific condition being treated and individual factors. Typically, adult doses range from 500 mg to 1500 mg of elemental calcium per day, divided into two to four doses. It is essential to follow the dosage instructions provided by the healthcare professional or as mentioned on the label.
Side Effects: Possible side effects of calcium supplementation may include:
1. Stomach upset or constipation
2. Nausea or vomiting
3. Increased thirst or frequent urination
4. Loss of appetite
5. Headache or dizziness
6. Weakness or fatigue
7. Increased risk of kidney stones, especially with long-term high-dose use
It is important to note that excessively high levels of calcium in the blood (hypercalcemia) can be dangerous and may require immediate medical attention. Symptoms of hypercalcemia include confusion, muscle weakness, irregular heartbeat, and excessive thirst or urination.
It is advisable to consult a healthcare professional before starting calcium supplementation to determine the appropriate dosage and monitor for any potential side effects or interactions with other medications.
Chromium Picolinate: Chromium picolinate is a nutritional supplement that contains the trace mineral chromium. It is commonly used to improve blood sugar control, promote weight loss, and enhance muscle building.
The precise mechanism of action of chromium picolinate is not fully understood, but it is believed to enhance the action of insulin, a hormone that helps regulate blood sugar levels. Chromium picolinate may improve insulin sensitivity, which allows cells to take up and use glucose more efficiently.
The recommended dose of chromium picolinate varies depending on the specific condition being treated. For blood sugar control, doses ranging from 200 to 1,000 mcg per day may be used. For weight loss and muscle building, doses of 200 to 600 mcg per day have commonly been used. It is important to follow the instructions provided on the product label or consult a healthcare professional for the appropriate dose.
Chromium picolinate is generally well tolerated when taken at appropriate doses. However, some individuals may experience side effects such as headaches, dizziness, skin rash, nausea, and changes in bowel movements. Rarely, high doses of chromium picolinate may cause kidney or liver damage. It is important to speak with a healthcare professional before starting chromium picolinate or any other supplement to ensure it is safe and appropriate for individual circumstances. Chromium picolinate should not be used as a replacement for prescribed diabetes medications without medical supervision.
Melatonin: Melatonin is a hormone that is naturally produced by the pineal gland in the brain and is involved in regulating the sleep-wake cycle. It is available as a supplement and is commonly used for sleep disorders, such as insomnia and jet lag.
The exact mechanism of action of melatonin is not fully understood, but it is thought to act on specific receptors in the brain, helping to regulate the sleep-wake cycle. Melatonin levels rise in the evening, promoting sleep, and decrease in the morning, signaling wakefulness.
The appropriate dose of melatonin varies depending on the individual and the condition being treated. For adults with sleep disorders, the typical dose is 0.3 to 5 mg taken one to two hours before bedtime. Higher doses may be used for certain conditions, but it is important to follow the recommended dosage guidelines and consult a healthcare professional for personalized advice.
Melatonin is generally considered safe for short-term use, but it can cause some side effects. Common side effects include drowsiness, headache, dizziness, and stomach discomfort. It may also cause vivid dreams or nightmares in some individuals. It is not recommended for use in pregnant or breastfeeding women, individuals with autoimmune disorders, or those taking certain medications, so it is important to consult with a healthcare professional before starting melatonin. Additionally, long-term safety and effectiveness of melatonin supplementation have not been well-studied, so it is generally recommended to use it for short periods of time. Overall, melatonin is widely used and considered safe, but individual responses and tolerability may vary.
Vitamin D3 (cholecalciferol): Vitamin D3, also known as cholecalciferol, is a fat-soluble vitamin that plays a crucial role in maintaining proper levels of calcium and phosphate in the body. It is primarily used as a dietary supplement to treat or prevent conditions related to vitamin D deficiency.
The main mechanism of action of vitamin D3 involves its activation in the body. When exposed to sunlight or obtained through dietary sources, vitamin D3 undergoes conversion in the liver and kidneys to its active form, known as calcitriol. Calcitriol then acts on various target tissues, such as the intestines, kidneys, and bones, to increase the absorption of calcium and phosphate. This helps promote bone health and prevents conditions like osteoporosis, rickets, and osteomalacia.
The recommended dosage of vitamin D3 may vary depending on the individual’s age, health condition, and the severity of the deficiency. However, the typical daily dose for adults is usually around 600-800 international units (IU) per day. Higher doses may be required for those with more severe deficiencies.
Common side effects of vitamin D3 supplementation are generally rare but may include nausea, vomiting, constipation, loss of appetite, and increased thirst. In rare cases, excessive intake of vitamin D3 can lead to vitamin D toxicity, resulting in symptoms such as weakness, fatigue, headache, increased urination, and kidney damage.
It is important to consult with a healthcare professional before starting vitamin D3 supplementation, as they can provide personalized dosage recommendations and monitor for any potential interactions or adverse effects. Additionally, getting regular sunlight exposure and consuming foods rich in vitamin D, such as fatty fish, fortified dairy products, and egg yolks, can help maintain adequate vitamin D levels.
L-Methylfolate: L-Methylfolate, also known as levomefolic acid or L-5-MTHF, is a medication that is primarily used as a dietary supplement or prescription medicine to treat certain deficiencies and conditions related to folate (vitamin B9) in the body. It is the active, bioavailable form of folate that can be directly used by the body.
L-Methylfolate plays a crucial role in supporting various metabolic processes in the body, including the synthesis of DNA, RNA, and neurotransmitters like serotonin, dopamine, and norepinephrine. It helps in the production and maintenance of new cells and is especially important during pregnancy for fetal development.
The medication is commonly prescribed to individuals with certain genetic variations that impair their ability to convert folic acid or dietary folate into the active form, L-Methylfolate. It may also be recommended for individuals with depression, particularly those who do not adequately respond to traditional antidepressant medications. In such cases, L-Methylfolate can enhance the effectiveness of antidepressants by replenishing the levels of folate in the brain.
The recommended dose of L-Methylfolate varies depending on the specific condition being treated. For general dietary supplementation, the typical dose is around 1-7.5 mg per day. When prescribed for depression, the dose may range from 7.5-15 mg per day, in combination with other antidepressants.
Like any medication, L-Methylfolate can cause certain side effects. Common side effects include mild gastrointestinal disturbances such as nausea, gas, bloating, and diarrhea. It may also rarely cause allergic reactions or skin rashes. In some cases, high doses of L-Methylfolate can lead to overstimulation and symptoms like restlessness, irritability, and insomnia.
It’s important to note that L-Methylfolate should be used under the guidance of a healthcare professional, who can determine the appropriate dose and monitor its effects on an individual basis.
Myo-Inositol: Myo-Inositol is a naturally occurring substance that is classified as a supplemental vitamin-like compound. It belongs to the family of sugar alcohols and is found abundantly in various foods, such as fruits, beans, and nuts. In recent years, it has gained attention for its potential therapeutic effects on various health conditions.
Myo-Inositol is primarily used as a supplement for women with polycystic ovary syndrome (PCOS). It has been found to improve insulin sensitivity and hormone balance in women with this condition, leading to regular menstrual cycles, increased ovulation, and improved fertility. Additionally, Myo-Inositol has shown promising results in managing symptoms of anxiety, depression, and obsessive-compulsive disorder (OCD).
The exact mechanism of action of Myo-Inositol is not fully understood but it is believed to involve several pathways in the body. It acts as a secondary messenger and plays a crucial role in the insulin signaling pathway, which helps regulate glucose metabolism. It also affects the balance of certain neurotransmitters in the brain, including serotonin and dopamine, which are involved in mood regulation.
The typical recommended dose of Myo-Inositol for PCOS is 2 to 4 grams per day, with higher doses commonly used for fertility purposes. It is usually taken orally as a powder or in capsule form. However, it is important to note that the appropriate dose may vary depending on the individual and their specific condition, so it is always best to consult with a healthcare professional for personalized guidance.
Overall, Myo-Inositol is considered safe and well-tolerated. Most people do not experience any significant side effects when using it. However, some individuals may experience mild digestive issues, such as nausea, bloating, or diarrhea when first starting the supplement. These side effects are typically temporary and subside over time. It is also worth mentioning that Myo-Inositol may interact with certain medications, so it is important to inform your healthcare provider about any other drugs you are taking before starting this supplement.
D-Chiro Inositol: D-Chiro Inositol (DCI) is a dietary supplement that is used for the management of various conditions such as polycystic ovary syndrome (PCOS), insulin resistance, and type 2 diabetes.
DCI acts as a signaling molecule in the insulin pathway and plays a crucial role in insulin regulation and glucose metabolism. In conditions like PCOS and insulin resistance, there is a deficiency of DCI, which leads to disturbances in insulin signaling. Supplementing with DCI helps restore the balance of insulin signaling and improves insulin sensitivity, thereby managing the symptoms of these conditions.
The recommended dose of DCI varies depending on the condition being treated. For PCOS, the typical dose is 1,200-2,400 mg per day. For insulin resistance, a dose of 400 mg per day is commonly used. It is essential to consult a healthcare professional to determine the appropriate dose for individual needs.
DCI is generally well-tolerated, and most people do not experience any significant side effects. However, like any other supplement, it may cause mild gastrointestinal distress such as nausea, bloating, or diarrhea in some individuals. These side effects are typically temporary and resolve on their own.
It is important to note that DCI may interact with certain medications, including medications for diabetes and blood sugar control. Therefore, it is crucial to consult a healthcare professional before starting DCI supplementation, especially if you are taking any other medications.
Overall, DCI is a dietary supplement that can be used to manage conditions like PCOS, insulin resistance, and type 2 diabetes. It acts by improving insulin signaling and glucose metabolism. When taken at the recommended dose, it is generally safe with minimal side effects. However, it is always advisable to consult a healthcare professional before starting any new supplement.
