CINNARIZINE + DOMPERIDONE
Cinnarizine: Cinnarizine is a medication primarily used for the prevention and treatment of various conditions related to the inner ear and vestibular system. It is commonly prescribed for the management of motion sickness and vertigo.
The exact mechanism of action of cinnarizine is not fully understood. However, it is believed to work by blocking the histamine H1 receptors in the brain and the smooth muscles of blood vessels. This action helps to reduce the sensitivity of the inner ear to motion and helps to improve blood flow to the brain.
When used to prevent motion sickness, cinnarizine is typically taken 1-2 hours before the travel or activity that may induce motion sickness. The usual adult dose is 25 mg, which can be repeated after every 6 hours if necessary. For the treatment of vertigo, the usual dose is 30-75 mg per day, divided into two or three doses.
As with any medication, cinnarizine may cause certain side effects. Common side effects include drowsiness, dry mouth, blurred vision, constipation, and gastrointestinal disturbances. Some people might experience dizziness or experience a decrease in alertness. These side effects are usually mild and go away on their own. However, if they persist or worsen, it is advisable to consult a healthcare professional.
In rare cases, individuals may experience more serious side effects such as increased heartbeat, irregular heartbeat, severe allergic reactions, difficulty breathing, and muscle stiffness. If any of these symptoms occur, medical help should be sought immediately.
It’s important to note that cinnarizine may interact with other medications, so it is essential to inform a healthcare professional about any other drugs being taken. Additionally, it is not recommended for use in individuals with a history of Parkinson’s disease, hypotension, or severe liver disease.
Overall, cinnarizine is an effective medication for preventing and treating motion sickness and vertigo. However, it is essential to follow the prescribed dose and monitor for any side effects, and consult a healthcare professional if any concerns arise.
Domperidone: Domperidone is a medication that belongs to the class of drugs known as dopamine antagonists. It is commonly used to treat gastrointestinal disorders such as nausea and vomiting. Domperidone is not available for prescription in some countries, including the United States, due to concerns about its potential cardiac side effects.
The main mechanism of action of Domperidone is to block dopamine receptors in the brain and gut. This action increases the movement and contraction of the stomach and intestines, which aids in the movement of food through the digestive system. Domperidone also has antiemetic properties, meaning it helps to prevent or reduce vomiting.
The recommended oral dose of Domperidone for adults and children over 12 years old is 10-20 mg taken three to four times a day, preferably before meals and at bedtime. The dose may be adjusted by a healthcare professional based on the individual’s response.
While Domperidone is generally well-tolerated, it can cause some side effects. Common side effects include headache, dizziness, dry mouth, and abdominal cramps. In rare cases, the drug may cause a potentially serious cardiac side effect known as prolongation of the QT interval, which can lead to an abnormal heart rhythm. Therefore, it is crucial to inform your healthcare provider about any existing heart conditions or history of a prolonged QT interval before taking Domperidone.
It’s important to note that the availability and recommended use of Domperidone may vary by country. Always consult with a healthcare professional or pharmacist for the most accurate and up-to-date information regarding the use and potential side effects of this medication.
