DOMPERIDONE + CINNARIZINE
Domperidone: Domperidone is a medication that belongs to the class of drugs known as dopamine antagonists. It is primarily used to relieve symptoms such as nausea, vomiting, bloating, and discomfort caused by various gastrointestinal conditions.
The main mechanism of action of Domperidone is to block dopamine receptors in the brain and gut, which helps to increase motility in the stomach and intestines. By enhancing gastrointestinal contractions and tightening the muscles at the lower end of the esophagus, Domperidone helps to facilitate the movement of food through the digestive system.
When taken orally, Domperidone is usually prescribed in a dose of 10-20 milligrams, half an hour before meals three to four times a day. The dosage may vary depending on the severity of symptoms and the individual’s response to treatment. It is important to follow the prescribed dose and duration as recommended by a healthcare professional.
While generally well-tolerated, Domperidone can have some potential side effects. Common side effects may include headache, dry mouth, abdominal cramps, drowsiness, and dizziness. These side effects are usually mild and transient.
In rare cases, Domperidone can lead to serious side effects such as cardiac arrhythmias (abnormal heart rhythms) or extrapyramidal symptoms (movement disorders). It should be used with caution in patients with pre-existing heart conditions or those taking other medications that may interact with Domperidone.
Domperidone is contraindicated in individuals with a history of liver disease, prolactinoma (a tumor of the pituitary gland), or who are allergic to the drug. It should also not be used in combination with certain medications that may increase the risk of adverse effects.
Before using Domperidone, it is essential to consult a healthcare professional who can weigh the potential benefits against the risks, considering the individual’s medical history and current medication regimen.
Cinnarizine: Cinnarizine is a medication primarily used to treat vertigo and motion sickness. It belongs to a class of drugs known as antihistamines.
The exact mechanism of action of cinnarizine is not fully understood. However, it is believed to work by blocking certain histamine receptors in the brain, specifically the H1 receptors. By doing so, it reduces the hyperexcitability of the vestibular system, which is responsible for maintaining balance and spatial orientation. This helps alleviate symptoms of vertigo and prevents motion sickness.
The usual starting dose of cinnarizine is 25 mg, taken one to three times daily. The dose can be adjusted based on the individual’s response and the severity of the condition. It is typically taken with or after meals to minimize gastrointestinal side effects.
Some common side effects of cinnarizine include drowsiness, dizziness, dry mouth, and constipation. These side effects are usually mild and transient. In rare cases, individuals may experience more severe side effects such as extrapyramidal symptoms (involuntary movements), blurred vision, or low blood pressure.
Cinnarizine should be used with caution in individuals with a history of Parkinson’s disease, epilepsy, or those who are susceptible to extrapyramidal symptoms. It is not recommended for use in pregnant or breastfeeding women and should be avoided in individuals with known hypersensitivity to the drug.
As with any medication, it is important to follow the prescribed dosage and consult a healthcare professional if any concerning side effects occur or if the symptoms do not improve.
