FOLIC ACID + L-ORNITHINE L-ASPARTATE + PYRIDOXIME HCI + SILYMARIN + METADOXINE
Folic Acid: Folic Acid, also known as folate or vitamin B9, is a water-soluble vitamin. It is used as a dietary supplement and medication for various conditions related to folate deficiency. Folic Acid plays a critical role in cell division, DNA synthesis, and the production of red blood cells. It is particularly important during pregnancy to promote the normal development of the baby’s brain and spinal cord.
Folic Acid works by acting as a coenzyme in several biochemical reactions involving the transfer of one-carbon units. It plays a crucial role in the synthesis of DNA, RNA, and proteins, which are essential for proper cell division and growth.
The recommended daily dose of Folic Acid varies depending on age, gender, and specific health needs. For most adults, including pregnant women, the recommended dose is around 400-800 micrograms per day. However, higher doses may be necessary for certain medical conditions.
Folic Acid is generally safe and well-tolerated when taken at the recommended doses. However, some people may experience mild side effects such as nausea, abdominal cramps, diarrhea, skin rash, or sleep disturbances. These side effects are usually temporary and resolve on their own.
In rare cases, high doses of Folic Acid may mask symptoms of vitamin B12 deficiency, leading to neurological damage if left untreated. Additionally, individuals with untreated vitamin B12 deficiency who take Folic Acid may exhibit worsening anemia symptoms. Therefore, it is important to monitor vitamin B12 levels when using Folic Acid supplements.
It’s worth noting that Folic Acid supplementation is necessary for women of childbearing age to prevent neural tube defects in pregnancy. However, it is always recommended to consult with a healthcare provider before starting any new medication or supplement, including Folic Acid, to ensure it is appropriate for your specific health needs.
L-Ornithine L-Aspartate: L-Ornithine L-Aspartate (LOLA) is a medication that is primarily used for the treatment of hepatic encephalopathy (a brain disorder that occurs due to liver disease). It acts by promoting the detoxification of ammonia in the body, which is typically elevated in individuals with liver dysfunction.
The mechanism of action of LOLA involves the conversion of ammonia to urea in the liver. It provides additional substrates for the urea cycle, enhancing the body’s ability to remove ammonia. This results in a decrease in ammonia levels, thereby improving symptoms associated with hepatic encephalopathy.
The standard dose of LOLA is 1-2 sachets (6-12 grams) orally, typically divided into two to three doses daily. It is usually recommended to be taken with meals. The dose may vary depending on the severity of hepatic encephalopathy and the patient’s response to treatment. It is important to consult a healthcare professional for personalized dosing instructions.
Side effects of LOLA are generally mild and uncommon. Some reported side effects include gastrointestinal disturbances such as diarrhea, nausea, and abdominal discomfort. Rarely, allergic reactions such as rash or itching may occur. If any severe or persistent side effects are experienced, it is important to seek medical attention.
It is essential to note that LOLA should only be taken under medical supervision and as prescribed by a healthcare professional. It is not recommended for use in individuals with hypersensitivity to any of its components or severe kidney dysfunction. Additionally, LOLA is not suitable for use in children and pregnant or breastfeeding women, unless specifically prescribed by a doctor.
As with any medication, it is important to discuss potential interactions with other drugs or medical conditions with a healthcare professional before starting LOLA.
Pyridoxime Hci: Pyridoxime HCl is a drug used in the treatment of various conditions related to vitamin B6 deficiency. It is a synthetic derivative of vitamin B6 (pyridoxine) and is available in oral and injectable forms.
The main use of Pyridoxime HCl is in the treatment of pyridoxine-dependent seizures, which occur in infants with a genetic disorder that impairs their ability to metabolize vitamin B6. Pyridoxime HCl is also used to treat certain drug-induced neurological conditions, such as those caused by the overdose of isoniazid, a medication used to treat tuberculosis.
The exact mechanism of action of Pyridoxime HCl is not well understood, but it is believed to work by replenishing the depleted levels of pyridoxal-5-phosphate, the active form of vitamin B6, in the body. Pyridoxime HCl also has a cholinesterase reactivating property, which can be helpful in cases of organophosphate poisoning.
The dose of Pyridoxime HCl depends on the specific condition being treated and the patient’s age and weight. It is usually administered under the supervision of a healthcare professional. For pyridoxine-dependent seizures, the typical dose is 50-100 mg/kg/day divided into multiple doses. In cases of isoniazid overdose, the initial dose is typically 5 grams followed by 1 gram every hour until symptoms improve.
As with any medication, Pyridoxime HCl can cause side effects. Common side effects include nausea, diarrhea, headache, dizziness, and allergic reactions such as rash or itching. Other rare side effects may include abnormal liver function tests, sensory neuropathy, and increased urinary frequency. It is important to consult a healthcare professional if any side effects are experienced.
Silymarin: Silymarin is a natural product derived from the seeds of the milk thistle plant (Silybum marianum). It is often used as an over-the-counter supplement and is known for its potential liver-protective properties.
Silymarin is primarily used to support liver health and aid in the treatment of liver diseases such as hepatitis, cirrhosis, and fatty liver disease. It is believed to have antioxidant, anti-inflammatory, and antifibrotic effects, which help protect liver cells from damage and promote their regeneration.
The recommended dose of silymarin varies depending on the formulation and brand. Generally, a typical dose ranges from 70 to 200 mg taken 2 to 3 times per day with meals. However, it is important to follow the specific dosing instructions provided on the product packaging or as directed by a healthcare professional.
As an herbal supplement, silymarin is generally considered safe and well-tolerated when used as directed. However, some individuals may experience mild gastrointestinal side effects such as upset stomach, diarrhea, or bloating. Allergic reactions, although rare, have also been reported.
It is important to note that despite its potential benefits, silymarin should not be used as a substitute for medical treatment or in place of prescribed medications for liver conditions. It is always recommended to consult with a healthcare professional before starting any new supplement or treatment.
Metadoxine: Metadoxine is a medication that is primarily used in the treatment of alcohol-related liver disease and acute alcohol intoxication. It is marketed under various brand names including Hepa-Merz, Eylon, and Duoxal.
The mechanism of action of metadoxine is not entirely understood, but it is believed to exert its therapeutic effects through several mechanisms. It acts as a central nervous system stimulant, enhancing cognitive function and attention. It also has antioxidant properties and helps to reduce liver inflammation and injury caused by alcohol consumption. Metadoxine is thought to improve liver function by enhancing the metabolism of alcohol and reducing the accumulation of toxic metabolites.
The standard dose of metadoxine for the treatment of alcohol-related liver disease is 500 mg taken orally three times a day. In cases of acute alcohol intoxication, a higher dose of 1000 mg can be administered intravenously. The duration of treatment depends on the severity of the condition and should be determined by a healthcare professional.
Common side effects of metadoxine may include gastrointestinal disturbances such as nausea, vomiting, and diarrhea. Other less common side effects can include headache, dizziness, dry mouth, and skin rash. It is important to note that adverse effects may vary from person to person and it is advisable to consult a healthcare professional for a complete list of possible side effects.
It is also worth mentioning that metadoxine should not be used as a substitute for responsible alcohol consumption and it does not have any direct effect on reducing or eliminating alcohol cravings. It is always best to seek professional advice and support for alcohol-related issues.
