GLYCERINE

GLYCERINE: Drug: Glycerine

Use: Glycerine, also known as glycerol, is a clear, colorless liquid that is used for various purposes in medicine. It is commonly used as a laxative to relieve occasional constipation or to soften hardened stools. It can also be used as a lubricant for certain medical procedures, as a moisturizer in skincare products, and as a solvent in certain medications.

Mechanism of action: Glycerine works as a laxative by drawing water into the intestines, increasing stool bulk and stimulating bowel movements. It is not fully understood how exactly it works as a lubricant, but it is thought to create a smooth surface that reduces friction during medical procedures. Glycerine also acts as a moisturizer by attracting and retaining moisture in the skin.

Dose: The dose of glycerine can vary depending on the purpose of its use. As a laxative, it is commonly available as a rectal suppository, with a typical dose of 1-2 suppositories (2-4 grams) inserted into the rectum as needed. It can also be used orally as a liquid, with a usual adult dose of 15-30 mL (1-2 tablespoons) once daily. The specific dosing instructions should be followed as directed by a healthcare professional.

Side effects: Common side effects of glycerine as a laxative include rectal irritation, burning, or itching. It may also cause mild abdominal discomfort or cramping. In some cases, excessive use of glycerine laxatives can lead to diarrhea, dehydration, or electrolyte imbalances. Allergic reactions to glycerine are rare but can occur and may manifest as skin rash, itching, or swelling. It is important to consult a healthcare professional if any unusual or severe side effects are experienced.