INDOMETHACIN
INDOMETHACIN: Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain, swelling, and inflammation in various conditions such as arthritis, bursitis, gout, and tendonitis. It belongs to the class of drugs known as cyclooxygenase (COX) inhibitors, specifically the COX-1 and COX-2 enzymes.
The main mechanism of action of indomethacin is by inhibiting the production of prostaglandins, which are substances in the body that promote inflammation, pain, and fever. This inhibition occurs through the blocking of the COX enzymes, thereby reducing the production of prostaglandins.
Indomethacin is available in oral capsule and suppository form. The typical dose for adults is around 25-50 mg two to three times a day. The dosage may vary depending on the specific condition being treated and the individual’s response to the medication. It is important to follow the prescribed dosage and duration as directed by a healthcare professional.
Like other NSAIDs, indomethacin can cause some side effects. Common side effects include stomach upset, heartburn, nausea, diarrhea, dizziness, headache, and drowsiness. It may also increase the risk of stomach ulcers and bleeding, especially in individuals who are older, have a history of stomach ulcers, or are taking other medications that can increase the risk of bleeding. Other serious side effects may include allergic reactions, high blood pressure, liver or kidney problems, and cardiovascular events such as heart attack or stroke. It is important to promptly report any unusual or severe side effects to a healthcare professional.
Indomethacin should be used with caution in individuals with a history of stomach ulcers, heart disease, high blood pressure, kidney or liver disease, asthma, or bleeding disorders. It is not recommended for use in the last trimester of pregnancy, as it may harm the unborn baby.
As with any medication, it is important to discuss the potential risks and benefits of using indomethacin with a healthcare professional, who can provide personalized advice and guidance based on an individual’s specific medical history and condition.
