LACTOBACILLUS + NICOTINAMIDE + PYRIDOXINE (VITAMIN B6) + RIBOFLAVINE + THIAMINE
Lactobacillus: Lactobacillus is a type of bacteria that is naturally found in the human body, especially in the digestive system, mouth, and vagina. It is also a commonly used probiotic, available in supplement form, to enhance the microbial balance in the gut.
The primary use of Lactobacillus is to promote digestive health and support a healthy immune system. It works by restoring and maintaining the natural balance of beneficial bacteria in the gut. This can be especially beneficial after the use of antibiotics, which can disrupt the balance of microbial flora in the intestines.
Lactobacillus supplements are available in various forms, including capsules, tablets, and powders. The dosage can vary depending on the specific product and the condition being treated. It is important to follow the instructions provided by the manufacturer or consult with a healthcare professional for the appropriate dosage.
Most people tolerate Lactobacillus well, and side effects are rare. However, some possible side effects may include bloating, gas, and mild gastrointestinal discomfort. These side effects are usually temporary and resolve on their own.
It is important to note that while Lactobacillus supplements are generally regarded as safe for most people, individuals with weakened immune systems or those undergoing invasive medical procedures should consult their healthcare provider before using any probiotic supplement, including Lactobacillus. Additionally, it is essential to purchase Lactobacillus supplements from reputable sources to ensure product quality and effectiveness.
Nicotinamide: Drug: Nicotinamide
Use:
Nicotinamide is a form of vitamin B3, also known as niacinamide. It is primarily used as a dietary supplement to treat vitamin B3 deficiency and prevent or treat pellagra, a condition caused by niacin deficiency. Nicotinamide can also be used as an adjuvant therapy in certain skin conditions like acne vulgaris and rosacea.
Mechanism of Action:
Nicotinamide is a precursor to nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+), coenzymes involved in various metabolic pathways. It plays a vital role in cellular energy production and DNA repair processes. Additionally, nicotinamide possesses anti-inflammatory properties.
Dose:
The recommended daily dose of nicotinamide varies depending on the purpose of use. For the treatment of pellagra, a typical dose ranges from 300 to 500 mg, taken orally 2-3 times a day. As an adjuvant therapy for skin conditions, a dose of 500 mg twice daily is commonly recommended. It is important to follow the instructions provided by a healthcare professional or the product label.
Side Effects:
Nicotinamide is generally well-tolerated and safe when used within the recommended dosage range. Common side effects may include flushing, nausea, vomiting, and diarrhea, especially at high doses. These side effects are usually mild and temporary.
Rare but severe allergic reactions to nicotinamide may occur, characterized by symptoms such as rash, itching, swelling, severe dizziness, and difficulty breathing. If any of these symptoms occur, immediate medical attention should be sought.
It is important to consult with a healthcare professional before starting nicotinamide or any other dietary supplement to determine the appropriate dosage, especially if you have any underlying medical conditions or are taking other medications.
Pyridoxine (vitamin B6): Drug: Pyridoxine (vitamin B6)
Use: Pyridoxine is a water-soluble vitamin used as a dietary supplement to treat deficiencies of vitamin B6. It is also used in certain medical conditions, including premenstrual syndrome (PMS), morning sickness during pregnancy, and symptoms of carpal tunnel syndrome.
Mechanism of Action: Pyridoxine acts as a coenzyme in many biochemical reactions in the body. It is involved in the metabolism of proteins, carbohydrates, and fats. It also plays a role in the production of neurotransmitters like serotonin, norepinephrine, and dopamine. These neurotransmitters are important in regulating mood, sleep, and other brain functions.
Dose: The recommended daily dose of pyridoxine varies depending on age, sex, and specific medical conditions. For adults, the typical dose ranges from 1.3 to 2 mg per day. Higher doses may be prescribed for certain conditions under medical supervision.
Side Effects: Pyridoxine is generally considered safe when taken orally in recommended doses. However, high doses of pyridoxine (over 200 mg per day) may lead to neurological side effects, including numbness, tingling, and impaired coordination. These symptoms are usually reversible upon discontinuation of the supplement. Long-term use of high doses may also cause peripheral neuropathy. Allergic reactions are rare but possible.
It is important to note that pyridoxine can interact with certain medications, including levodopa, certain seizure medications, and certain cancer drugs. Therefore, it is crucial to consult with a healthcare professional before starting pyridoxine or making any changes to the existing medication regimen.
Riboflavine: Riboflavine, also known as vitamin B2, is a water-soluble vitamin that is essential for the body’s energy production and metabolism. It is commonly used as a nutritional supplement to treat riboflavin deficiency and prevent related health conditions.
Riboflavine functions as a cofactor in many enzyme reactions involved in the metabolism of carbohydrates, fats, and proteins. It is necessary for the conversion of food into energy and also acts as an antioxidant, protecting cells from oxidative stress. Riboflavine is absorbed in the small intestine and is stored in the liver, where it is converted to its active form, flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN).
The recommended daily dose of riboflavine varies depending on age, sex, and specific health conditions. For adults, the typical dose is around 1.3 mg for males and 1.1 mg for females. Higher doses may be recommended for individuals with riboflavin deficiency or certain medical conditions.
While riboflavine is generally considered safe, it can cause some side effects, although they are rare. Common side effects include urine discoloration (yellow-orange), increased sensitivity to light (photosensitivity), and itching or burning sensation in the eyes. These side effects are usually temporary and resolve on their own.
In some cases, high doses of riboflavine can cause diarrhea, increased urine output, or allergic reactions such as rash, itching, or swelling. If any of these side effects persist or worsen, it is important to seek medical attention.
It is worth noting that riboflavine is generally well-tolerated when consumed in the recommended doses. However, it is always advisable to consult a healthcare professional before starting any new supplement to ensure it is safe and appropriate for an individual’s specific health needs.
Thiamine: Thiamine, also known as vitamin B1, is a water-soluble vitamin that plays a crucial role in carbohydrate metabolism. It is used as a supplement to treat or prevent thiamine deficiency, which can lead to conditions such as beriberi or Wernicke-Korsakoff syndrome.
The primary mechanism of action of thiamine is its conversion into its active form, thiamine pyrophosphate (TPP), which is an essential cofactor for several key enzymes involved in carbohydrate metabolism. TPP facilitates the conversion of pyruvate to acetyl-CoA, which is necessary for the production of adenosine triphosphate (ATP) – the currency of energy in the body.
For the treatment of thiamine deficiency in adults, the recommended dose is generally 5-30 mg per day, taken orally. In severe cases, higher doses may be required, and these are usually given via injection. Dosages for children are usually lower and should be determined by a healthcare professional.
Common side effects of thiamine supplementation are rare, but may include upset stomach, nausea, headache, and a feeling of warmth. Allergic reactions are possible, but very uncommon. In rare cases, high doses of thiamine given by injection can cause anaphylactic shock, which is a severe allergic reaction that requires immediate medical attention.
It’s important to note that thiamine supplements should not be used in place of a balanced diet. The best way to ensure adequate thiamine intake is by consuming foods rich in thiamine, such as whole grains, legumes, nuts, seeds, and lean meats. Thiamine deficiency is generally rare in developed countries, as most people consume enough through their diet.
