MEMANTINE

MEMANTINE: Drug: Memantine
Brand names: Namenda, Ebixa, Axura

Use: Memantine is used to treat moderate to severe dementia associated with Alzheimer’s disease.

Mechanism of action: Memantine is a selective NMDA receptor antagonist. It works by regulating glutamate, a neurotransmitter involved in many brain functions. In Alzheimer’s disease, there is an excessive release of glutamate, leading to cell damage. Memantine blocks the effects of glutamate, reducing the damage to brain cells.

Dose: The typical starting dose for memantine is 5 mg once daily. The dose is then gradually increased over several weeks, reaching a target maintenance dose of 20 mg per day, divided into two doses of 10 mg each. Dosage adjustments may be necessary based on individual response and tolerability.

Side effects: Common side effects of memantine may include dizziness, headache, constipation, confusion, and sleep disturbances. Less common side effects may include hallucinations, agitation, aggression, and increased blood pressure. It is important to seek medical help if any severe side effects occur.

Note: This description is for informational purposes only and should not replace professional medical advice. Always consult a healthcare professional before starting or altering any medication.