METHYLCOBALAMIN + CALCITRIOL + CALCIUM CITRATE + L-METHYLFOLATE + CISSUS QUADRANGULARIS (HADJOD) + VITAMIN K2-7 (MENAQUINONE-7)
Methylcobalamin: Methylcobalamin is a form of Vitamin B12 that is used as a dietary supplement and medication. It is essential for the proper functioning of the nervous system and the production of red blood cells.
Methylcobalamin works by restoring and maintaining adequate levels of Vitamin B12 in the body. It is actively involved in the conversion of homocysteine to methionine, a process that is crucial for the production of DNA, RNA, and proteins. Additionally, it plays a vital role in the synthesis of myelin, a protective covering around nerves that allows for proper nerve function.
The dose of methylcobalamin can vary depending on the condition being treated. It can be taken orally as a tablet or capsule, or administered as an injection. For vitamin B12 deficiency, the recommended dose is typically 1000 to 2000 micrograms taken once daily or weekly, depending on the severity of the deficiency. If being used to treat certain neurological conditions like peripheral neuropathy, higher doses may be required and can be administered via injections.
Most people tolerate methylcobalamin well, but like any medication, it may have potential side effects. Common side effects may include mild diarrhea, nausea, headache, or skin rash. These side effects are generally mild and resolve on their own. However, if you experience any severe or persistent side effects, it is important to seek medical attention.
It is worth noting that methylcobalamin is generally considered safe for most individuals. However, if you have any existing health conditions or are taking other medications, it is important to consult with a healthcare professional before starting methylcobalamin supplementation.
Calcitriol: Drug Name: Calcitriol
Use:
Calcitriol is a synthetic form of vitamin D that is used to treat conditions caused by low levels of calcium or vitamin D in the body. It is prescribed to manage hypocalcemia (low blood calcium levels) and hypoparathyroidism (underactive parathyroid glands). Additionally, calcitriol is used in the prevention and treatment of osteoporosis and for the management of renal osteodystrophy in patients with chronic kidney disease.
Mechanism of Action:
Calcitriol works by increasing the absorption of calcium from the intestines and promoting the release of calcium from bones into the bloodstream. This helps to maintain adequate levels of calcium in the body, which is important for strong bones, normal nerve and muscle function, and other physiological processes.
Dose:
The dosing of calcitriol varies depending on the condition being treated and individual patient factors. It is available in oral capsules and as an injectable formulation. The dosage and frequency should be determined by a healthcare professional based on the patient’s specific needs. It is important to follow the prescribed dose and do not exceed it without consulting a doctor.
Side Effects:
Common side effects of calcitriol include nausea, vomiting, constipation, loss of appetite, headache, weakness, and dry mouth. These side effects are usually mild and can be managed. However, if they persist or become severe, medical attention should be sought.
Serious side effects are rare but can occur. These may include high blood calcium levels (hypercalcemia), which can manifest as symptoms such as increased thirst, frequent urination, confusion, muscle weakness, or an irregular heartbeat. If any of these severe side effects occur, immediate medical attention is necessary.
It is important to inform a healthcare provider about any known allergies or pre-existing medical conditions before starting calcitriol. Also, certain medications can interact with calcitriol, so it is essential to inform the doctor about all current medications, including over-the-counter drugs and supplements, to avoid potential drug interactions or complications.
Calcium Citrate: Calcium citrate is a medication that contains calcium in the form of calcium citrate salt. It is commonly used as a dietary supplement and as a medication to prevent or treat calcium deficiency in the body.
The main mechanism of action of calcium citrate is its ability to provide calcium ions for various physiological processes in the body. Calcium is an essential mineral that plays a vital role in bone health, muscle contraction, nerve signaling, and blood clotting. Calcium citrate is easily absorbed by the body in comparison to other forms of calcium, making it an ideal choice for people with low stomach acid or those who are taking medications that decrease stomach acid production.
The recommended dose of calcium citrate depends on the individual’s age, health condition, and the specific reason for taking the medication. It is important to follow the dosage instructions provided by the healthcare provider or as indicated on the packaging.
While calcium citrate is generally considered safe and well-tolerated, some side effects may occur. These can include constipation, stomach upset, gas, and bloating. In rare cases, excessive intake of calcium citrate can lead to hypercalcemia (high levels of calcium in the blood), which can cause symptoms like abdominal pain, nausea, vomiting, and confusion.
It is important to note that calcium citrate may interact with certain medications, such as antibiotics, bisphosphonates, and thyroid hormones, so it is advisable to consult a healthcare professional before taking this medication, especially if you have any underlying health conditions or are taking other medications.
L-Methylfolate: L-Methylfolate is a prescription medication that is used to treat certain types of depression and to improve cognitive function in individuals with certain mental disorders.
The mechanism of action of L-Methylfolate involves its role in the synthesis of neurotransmitters such as serotonin, dopamine, and norepinephrine. L-Methylfolate is the activated form of folic acid, and it plays a crucial role in methylation reactions in the body. Methylation is involved in the production of neurotransmitters and the regulation of mood. By providing a ready supply of methyl groups, L-Methylfolate helps to support the production of neurotransmitters, which can have a positive impact on mood and cognitive function.
The dose of L-Methylfolate can vary depending on the specific condition being treated and the individual’s response to the medication. It is typically taken orally, and the recommended dose typically ranges between 7.5 mg and 15 mg per day. The medication should be taken as directed by a healthcare professional.
Some of the commonly reported side effects of L-Methylfolate include mild gastrointestinal symptoms such as nausea, vomiting, and diarrhea. In some cases, it may also cause a rash or allergic reaction. It is important to consult a healthcare professional if any side effects are experienced, as they can provide guidance and support.
It is worth noting that L-Methylfolate is not a standalone treatment for depression or cognitive disorders. It is often used in combination with other medications and therapies as part of a comprehensive treatment plan. Therefore, it is important to follow the advice and recommendations of a healthcare professional when taking L-Methylfolate.
Cissus Quadrangularis (hadjod): Cissus quadrangularis, commonly known as hadjod, is a medicinal plant used in traditional medicine for various purposes. It is an ancient herb native to Asia, Africa, and the Arabian Peninsula. The plant is known for its medicinal properties due to the presence of various bioactive compounds.
Use: Cissus quadrangularis has been traditionally used for the treatment of bone fractures, joint pain, and other bone-related disorders. It is also used for its anti-inflammatory and analgesic properties. Currently, it is marketed as a dietary supplement for joint health and weight loss.
Mechanism of Action: The exact mechanism of action of Cissus quadrangularis is not fully understood. However, it is believed to work through multiple mechanisms. The plant contains compounds such as flavonoids, triterpenoids, and beta-sitosterol, which have anti-inflammatory and antioxidant effects. It may help in reducing inflammation and pain associated with bone and joint disorders. It also promotes bone healing and may have anabolic effects on bones.
Dose: The recommended dosage of Cissus quadrangularis varies depending on the form of the supplement and the specific condition it is being used for. Generally, the suggested dose is around 500-1500 mg per day, divided into multiple doses. It is advisable to follow the instructions on the product label or consult a healthcare professional for the appropriate dosage.
Side Effects: Cissus quadrangularis is generally considered safe when taken at the recommended doses. However, few individuals may experience some side effects, which are usually mild and transient. These side effects may include gastrointestinal symptoms such as stomach discomfort, nausea, and diarrhea. Allergic reactions are rare but possible. As with any supplement, it is advisable to consult a healthcare professional before starting Cissus quadrangularis to ensure its safe and appropriate use, especially if you have any pre-existing medical conditions or are taking any medications.
Vitamin K2-7 (menaquinone-7): Vitamin K2-7, also known as menaquinone-7, is a form of vitamin K that naturally occurs in certain fermented foods. It is a fat-soluble vitamin that plays a crucial role in maintaining bone and cardiovascular health.
The primary use of vitamin K2-7 is for the promotion of healthy bone metabolism and prevention of osteoporosis. It works by activating proteins that are involved in calcium metabolism, helping to ensure that calcium is properly utilized and deposited in bone tissue. This activity helps to strengthen bones and reduce the risk of fractures.
In addition to its effects on bone health, vitamin K2-7 also has cardiovascular benefits. It helps to prevent the accumulation of calcium in the arteries, which can reduce the risk of arterial calcification and lower the incidence of cardiovascular diseases such as heart attacks and strokes.
The recommended dose of vitamin K2-7 varies depending on the specific health needs of an individual. Generally, a daily dose of 100-200 micrograms is recommended for bone health. However, higher doses may be required for individuals with specific conditions such as osteoporosis.
Vitamin K2-7 is generally considered safe and well-tolerated when taken at recommended doses. However, excessive intake of vitamin K2-7 may cause mild side effects such as gastrointestinal disturbances, including nausea and diarrhea. It is important to consult with a healthcare professional before starting any new vitamin supplementation to ensure proper dosing and to avoid any potential interactions with other medications.
