MONTELUKAST + DOXOPHYLLINE
Montelukast: Montelukast is a medication that belongs to a class of drugs known as leukotriene receptor antagonists. It is commonly used for the prevention and long-term treatment of asthma in both adults and children, as well as for the relief of symptoms associated with seasonal allergic rhinitis (hay fever) in adults and children over the age of 2.
The mechanism of action of montelukast involves blocking the action of leukotrienes, which are substances that are released in the body in response to certain triggers, such as allergens or irritants. These leukotrienes cause inflammation and constriction of the airways, leading to symptoms of asthma. By inhibiting the activity of leukotrienes, montelukast helps to reduce inflammation, swelling, and constriction of the airways, thereby providing relief from symptoms and improving breathing.
The usual dose of montelukast for asthma in adults and adolescents (15 years and older) is 10 mg once daily. For children between the ages of 6 and 14, the recommended dose is 5 mg once daily. For children aged 2 to 5, the dose is 4 mg once daily. The medication can be taken with or without food.
Like any medication, montelukast may cause side effects. The most common side effects include headache, gastrointestinal disturbances (such as upset stomach, diarrhea, and nausea), and flu-like symptoms. Other side effects that may occur, though less frequently, include allergic reactions (such as rash, itching, or swelling), mood or behavior changes (such as agitation or depression), and sleep disturbances. It is important to consult a healthcare professional if any side effects are experienced, as they may require medical attention.
Doxophylline: Doxophylline is a medication that is used to treat respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). It belongs to a class of drugs known as bronchodilators, which work by relaxing the muscles in the airways and improving airflow to the lungs.
The exact mechanism of action of doxophylline is not fully understood, but it is believed to work by inhibiting an enzyme called phosphodiesterase, which prevents the breakdown of a substance called cyclic adenosine monophosphate (cAMP). Increased levels of cAMP in the airway smooth muscles result in relaxation and bronchodilation, thereby improving breathing.
Doxophylline is available in tablet form and is typically taken orally. The recommended dose depends on various factors, such as the patient’s age, weight, and the severity of their condition. It is important to follow the prescribed dosage and instructions provided by the healthcare professional.
Like any medication, doxophylline can cause side effects. Common side effects include nausea, vomiting, stomach pain, headache, dizziness, flushing, and increased heart rate. These side effects are usually mild and go away on their own. However, if any side effects persist or worsen, it is important to consult a healthcare professional.
In rare cases, doxophylline can cause more serious side effects such as allergic reactions, irregular heartbeat, chest pain, or difficulty breathing. If any of these symptoms occur, immediate medical attention should be sought.
It is important to note that doxophylline may interact with certain medications, so it is essential to inform your healthcare provider about any other medications or supplements you are taking before starting doxophylline.
Overall, doxophylline is a bronchodilator frequently used to help manage respiratory conditions such as asthma and COPD. It works by relaxing the airway muscles and improving airflow. While it is generally well-tolerated, it can cause side effects, and close monitoring by a healthcare professional is recommended during treatment.
