PHENFORMIN

PHENFORMIN: Phenformin is an antidiabetic drug that belongs to the biguanide class of medications. It was previously used to treat type 2 diabetes mellitus but is no longer available in most countries due to its association with serious side effects.

The main mechanism of action of phenformin is to lower blood sugar levels by decreasing the production of glucose in the liver and improving insulin sensitivity in peripheral tissues. It works by activating an enzyme called AMP-activated protein kinase (AMPK), which regulates cellular energy metabolism.

The usual starting dose of phenformin is 250 mg taken orally once or twice a day with meals. The dose can be gradually increased up to a maximum of 1 gram per day, divided into multiple doses. However, it is important to note that the dosing information mentioned here is for informational purposes only, as phenformin is no longer widely prescribed due to safety concerns.

Phenformin is associated with a number of side effects, some of which can be serious. The most common side effects include gastrointestinal disturbances such as diarrhea, nausea, and abdominal discomfort. These symptoms often subside over time as the body adjusts to the medication. However, phenformin has been linked to a higher risk of lactic acidosis, a potentially life-threatening condition characterized by the accumulation of lactic acid in the blood. Due to this risk, phenformin has been withdrawn from use in many countries.

As phenformin is no longer widely available, it is crucial to consult with a healthcare professional for up-to-date information on the treatment options available for type 2 diabetes.