ROFECOXIB

ROFECOXIB: Rofecoxib is a nonsteroidal anti-inflammatory drug (NSAID) that was used to relieve pain and inflammation associated with various conditions such as osteoarthritis and menstrual cramps. It belonged to the class of medications known as selective cyclooxygenase-2 (COX-2) inhibitors.

The mechanism of action of rofecoxib involved inhibiting the enzyme COX-2, which is responsible for producing chemicals called prostaglandins that are involved in inflammation and pain. By selectively targeting COX-2, rofecoxib reduced the production of prostaglandins without affecting the enzyme COX-1, which is involved in normal bodily functions like protecting the stomach lining.

The recommended dose of rofecoxib varied depending on the condition being treated, but it usually ranged from 12.5 to 50 mg per day. It was typically taken orally, with or without food.

However, it is important to note that rofecoxib was withdrawn from the market in 2004 due to concerns about an increased risk of cardiovascular events such as heart attack and stroke. Several studies had shown an association between long-term use of rofecoxib and these serious cardiovascular side effects. As a result, the drug was voluntarily withdrawn by the manufacturer.

Other side effects associated with rofecoxib included gastrointestinal issues such as stomach pain, indigestion, and ulcers. It could also cause fluid retention, leading to swelling in the legs and ankles. Some individuals may have experienced allergic reactions such as rash, itching, or difficulty breathing when taking rofecoxib.

Please note that this information is for educational purposes only and should not replace the advice of a healthcare professional.