TERBINAFINE + MOMETASONE FUROATE
Terbinafine: Terbinafine is a medication primarily used to treat fungal infections of the skin, nails, and scalp. It belongs to a class of drugs called antifungals.
The main mechanism of action of terbinafine is the inhibition of an enzyme called squalene epoxidase, which is vital for the synthesis of ergosterol, a key component of fungal cell membranes. By blocking this enzyme, terbinafine disrupts the integrity of the fungal cell membrane, ultimately leading to the death of the fungal organism.
Terbinafine is available in various formulations, including oral tablets, topical creams, and solutions. The choice of formulation depends on the location and severity of the infection. Oral tablets are commonly used for treating nail infections, while creams and solutions are suitable for skin infections.
The dosing regimen for terbinafine may vary depending on the condition being treated. For nail infections, the typical dose is 250 mg taken once daily for 6 to 12 weeks, while for skin infections, topical application of the cream or solution is generally done once or twice daily for 1 to 4 weeks. It is important to follow the prescribed dosage and duration of treatment as directed by a healthcare professional.
Common side effects of terbinafine include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal pain. Headache, dizziness, and skin rash can also occur. Severe side effects are rare but may include liver problems, changes in taste or smell perception, and allergic reactions.
It is worth noting that terbinafine can interact with certain medications, so it is important to inform your healthcare provider about all other medications (prescription, over-the-counter, or herbal) you are taking before starting treatment with terbinafine.
Overall, terbinafine is an effective antifungal drug with a well-established role in treating various fungal infections. However, it should only be used under the guidance of a healthcare professional, and any concerns or questions should be discussed with them.
Mometasone Furoate: Mometasone furoate is a synthetic glucocorticoid medication that is mainly used as a nasal spray to treat symptoms of allergic rhinitis (such as sneezing, congestion, runny nose, and itching) and nasal polyps. It is also available in topical formulations for the treatment of various skin conditions like eczema, psoriasis, and dermatitis.
The mechanism of action of mometasone furoate involves its binding to glucocorticoid receptors present in cells within the nasal mucosa or skin. Upon binding, it modifies the transcription of certain genes, leading to a decrease in the production of inflammatory mediators like cytokines, leukotrienes, and prostaglandins. This reduces the inflammation and itching associated with allergic reactions or skin conditions.
The usual dose of mometasone furoate nasal spray for adults and children above 12 years of age is usually two sprays into each nostril once daily. For children between the ages of 2 to 11 years, the recommended dose is one spray into each nostril once daily. The dose may vary depending on the individual and severity of symptoms, so it’s important to follow the instructions provided by the healthcare professional or mentioned in the product package.
As with any medication, mometasone furoate may cause side effects. The common side effects of the nasal spray include nasal irritation, nosebleeds, headache, pharyngitis (sore throat), and cough. In some cases, it may cause localized fungal infections in the nose or throat. Prolonged or excessive use of the nasal spray may also lead to systemic side effects like adrenal suppression, growth retardation in children, and vision problems.
In topical formulations, mometasone furoate may cause side effects such as skin thinning, skin discoloration, itching, and burning sensation at the application site. These side effects are usually rare and occur with prolonged and excessive use. It is important to follow the prescribed dose and duration of use to minimize the risk of side effects.
It is advisable to consult a healthcare professional for proper guidance on the use of mometasone furoate and to discuss any potential side effects or drug interactions before starting the medication.
