TERIPARATIDE

TERIPARATIDE: Teriparatide is a drug used for the treatment of osteoporosis. It is also known by its brand name Forteo.

Mechanism of action: Teriparatide is a synthetic form of human parathyroid hormone (PTH). PTH helps regulate calcium and phosphate levels in the body. Teriparatide works by stimulating bone formation, increasing bone mineral density, and reducing the risk of fractures. It does this by activating osteoblasts (bone-forming cells) and increasing the number and activity of these cells.

Use: Teriparatide is used in postmenopausal women and men at high risk of fractures due to osteoporosis, as well as in patients with a history of osteoporotic fractures or those who have failed or cannot tolerate other osteoporosis treatments.

Dose: The recommended dose of teriparatide is a daily subcutaneous injection of 20 mcg. It is typically injected into the thigh or abdomen. The treatment duration is limited to a maximum of two years.

Side effects: Common side effects of teriparatide include nausea, dizziness, leg cramps, headache, and injection site reactions such as pain, redness, or swelling. It may also cause an increase in blood calcium levels, which can lead to hypercalcemia. Patients with a history of bone cancer or skeletal radiation therapy should not use teriparatide. There is also a potential risk of osteosarcoma (a rare type of bone cancer) associated with long-term use of teriparatide, although this risk is still unclear and controversial. It is important to discuss potential risks and benefits with a healthcare provider before starting teriparatide therapy.