VITAMIN B3 (NIACINAMIDE) + THIAMINE + PYRIDOXINE (VITAMIN B6) + D-PANTHENOL + MEHTYL COBALAMINE
Vitamin B3 (niacinamide): Vitamin B3, also known as niacinamide, is a water-soluble vitamin that plays a crucial role in the synthesis of energy from food and the maintenance of a healthy nervous system. It is commonly used as a dietary supplement to treat or prevent deficiencies of vitamin B3.
Niacinamide functions as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in various metabolic reactions in cells. It helps convert food into energy, supports DNA repair, and aids in the proper functioning of the skin, digestive system, and nervous system.
In addition to its role as a vitamin, niacinamide has also been used therapeutically for various conditions. It can help manage symptoms of pellagra, a niacin deficiency disease, and has been utilized in the treatment of certain skin conditions, such as acne and rosacea.
The recommended daily dose of niacinamide varies depending on age, sex, and specific health conditions. For adults, the recommended intake is typically around 14-16 mg per day. However, higher doses may be prescribed for therapeutic purposes. It is important to follow the guidance of a healthcare professional regarding dosing.
Niacinamide is generally considered safe when taken within the recommended doses. However, higher doses may lead to certain side effects. Common side effects of niacinamide include flushing of the skin, a red and warm sensation, itching, and headaches. These side effects are usually mild and subside over time. In rare cases, high doses of niacinamide can cause liver toxicity, gastrointestinal upset, and changes in blood sugar levels.
It is essential to consult with a healthcare provider before starting any new supplement, including niacinamide. They can provide guidance on proper dosing and evaluate potential interactions with other medications or health conditions.
Thiamine: Thiamine, also known as vitamin B1, is a medication used to treat or prevent thiamine deficiency. Thiamine is an essential nutrient that plays a crucial role in the metabolism of carbohydrates. The medication is usually prescribed to individuals who are at risk of thiamine deficiency, such as those with alcohol dependence, malnutrition, or malabsorption disorders.
Thiamine works by helping the body convert carbohydrates into energy. It acts as a coenzyme in various enzyme reactions in the body, which are necessary for the metabolism of carbohydrates. Thiamine also plays a vital role in the functioning of the nervous system, muscles, and heart.
The standard recommended adult oral dose of Thiamine is 5-30 mg per day, either as a single dose or divided into multiple doses. For individuals with severe deficiency, higher doses may be required, up to 250 mg per day. The dosage may vary based on the specific condition being treated and the individual’s response to treatment. Thiamine can be taken with or without food.
Common side effects of Thiamine are rare but may include upset stomach, nausea, and allergic reactions such as rash or itching. These side effects are generally mild and resolve on their own. However, if you experience any severe or persistent side effects, it is important to contact your healthcare provider.
Thiamine is generally considered safe for most individuals. However, if you have certain medical conditions, such as congestive heart failure or renal impairment, or if you are taking certain medications, it is important to inform your doctor before starting Thiamine.
Overall, Thiamine is an essential nutrient that plays a vital role in metabolism and the functioning of the nervous system. It is commonly used to treat or prevent thiamine deficiency in individuals at risk. It is generally well-tolerated, but it is important to follow the recommended dose and consult with a healthcare professional for personalized dosage instructions and to monitor any potential side effects.
Pyridoxine (vitamin B6): Pyridoxine, commonly known as vitamin B6, is a water-soluble vitamin that is vital for various bodily functions. It is naturally found in many foods, including fish, poultry, whole grains, nuts, and bananas. Pyridoxine is available as a supplement and is also added to some fortified foods.
Pyridoxine is primarily used to treat and prevent vitamin B6 deficiency. It is involved in over 100 enzymatic reactions in the body, including the metabolism of amino acids, carbohydrates, and neurotransmitters. It is also necessary for the production of red blood cells and the synthesis of DNA and RNA.
The recommended daily dose of pyridoxine varies depending on age and gender. For adults, the recommended daily intake is 1.3 to 1.7 mg. Higher doses may be prescribed for individuals with certain medical conditions or specific dietary requirements.
Side effects of pyridoxine are rare when taken at recommended doses. However, high doses of pyridoxine over a long period of time can result in toxicity, known as vitamin B6 toxicity. Symptoms of toxicity may include numbness, tingling in the extremities, difficulty coordinating movements, and photosensitivity.
Pyridoxine may interact with certain medications, such as antiepileptic drugs, which can increase the risk of seizures. It may also interact with certain antibiotics, reducing their effectiveness.
It is important to consult with a healthcare professional before starting pyridoxine supplementation to ensure proper dosage and to assess for any potential drug interactions.
D-Panthenol: D-Panthenol, also known as Dexpanthenol, is a synthetic form of vitamin B5, available in various forms such as creams, ointments, and oral supplements.
Uses:
D-Panthenol is primarily used for its topical application in treating various skin conditions. It is commonly used in skincare products, such as moisturizers, to improve hydration and promote skin healing. D-Panthenol is also used in the treatment of skin irritations, burns, sunburns, and wounds. It can be found in hair products to strengthen and moisturize hair, reducing breakage and improving overall hair health.
Mechanism of Action:
Once applied topically or ingested, D-Panthenol is converted to pantothenic acid, an essential nutrient involved in the synthesis of coenzyme A. Coenzyme A plays a crucial role in the metabolism of carbohydrates, fats, and proteins, as well as in the production of energy. D-Panthenol helps to attract and retain water in the skin, improving its hydration and elasticity. It also promotes cell proliferation and the regeneration of damaged tissues, aiding in wound healing and reducing inflammation.
Dosage:
The dosage of D-Panthenol varies depending on the form and the specific condition being treated. For topical products such as creams or ointments, it is typically applied to the affected area 2-3 times a day, or as directed by a healthcare professional. Oral supplements of D-Panthenol should be taken as per the recommended dose on the packaging or as advised by a healthcare professional.
Side Effects:
The use of D-Panthenol is generally safe, with very rare reports of adverse effects. However, some individuals may experience mild skin irritation, redness, or allergic reactions when using topical products. If any severe or persistent side effects occur, it is important to discontinue use and seek medical attention.
It is always recommended to consult with a healthcare professional before using any medication, including D-Panthenol, to ensure proper usage and minimize potential risks.
Mehtyl Cobalamine: Methylcobalamin is a form of vitamin B12 that is used clinically for the treatment of vitamin B12 deficiency and certain neurological disorders. It is an active form of vitamin B12 that plays a crucial role in various physiological processes, including the synthesis of DNA, the formation of red blood cells, and the functioning of the nervous system.
The mechanism of action of methylcobalamin involves its conversion into coenzyme B12, which is involved in the conversion of homocysteine to methionine, and the conversion of methylmalonyl-CoA to succinyl-CoA. These processes are important for the proper functioning of nerve cells and the production of myelin, a protective coating around nerves.
The dose of methylcobalamin depends on the specific indication and should be determined by a healthcare professional. Typically, it is administered orally or by injection.
As for side effects, methylcobalamin is generally considered safe and well-tolerated. However, in some cases, it may cause mild side effects like diarrhea, nausea, or itching. Allergic reactions are rare but can occur. It is important to follow the recommended dosage and consult a healthcare professional if any adverse effects are experienced.
It’s worth noting that methylcobalamin is different from cyanocobalamin, another form of vitamin B12. While both are used for the treatment of vitamin B12 deficiency, methylcobalamin is preferred for neurological conditions due to its better bioavailability and retention in the body.
